Overview

  • Product name

    Anti-CaMKII alpha antibody
    See all CaMKII alpha primary antibodies
  • Description

    Rabbit polyclonal to CaMKII alpha
  • Host species

    Rabbit
  • Specificity

    This antibody does cross-react with CAMKII beta protein
  • Tested applications

    Suitable for: WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptidefrom around aa 284-288 (

    Q-E-T-V-D

    ) of Human CaMKII alpha (NP_150284.1).

  • Positive control

    • Human hippocampal region tissue; extracts from mouse brain tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab131468 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 50 kDa (predicted molecular weight: 54 kDa).
ICC/IF 1/100 - 1/200.

Target

  • Function

    CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.
  • Sequence similarities

    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
    Contains 1 protein kinase domain.
  • Cellular localization

    Cell junction > synapse > presynaptic cell membrane. Cell junction > synapse. Postsynaptic lipid rafts.
  • Information by UniProt
  • Database links

  • Alternative names

    • Alpha CaMKII antibody
    • Calcium calmodulin dependent protein kinase II antibody
    • Calcium/calmodulin dependent protein kinase II alpha B subunit antibody
    • Calcium/calmodulin dependent protein kinase type II alpha chain antibody
    • Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha antibody
    • Calcium/calmodulin-dependent protein kinase II alpha antibody
    • Calcium/calmodulin-dependent protein kinase II-alpha antibody
    • Calcium/calmodulin-dependent protein kinase type II subunit alpha antibody
    • Calcium/calmodulin-dependent protein kinase type IIA antibody
    • CaM kinase II alpha chain antibody
    • CaM kinase II alpha subunit antibody
    • CaM kinase II subunit alpha antibody
    • CaMK II alpha subunit antibody
    • CaMK-II subunit alpha antibody
    • Camk2a antibody
    • CAMKA antibody
    • CaMKII antibody
    • CaMKIINalpha antibody
    • EC 2.7.11.17 antibody
    • KCC2A_HUMAN antibody
    • KIAA0968 antibody
    • MGC123320 antibody
    • MGC139375 antibody
    • MGC155201 antibody
    • mKIAA0968 antibody
    • PK2CDD antibody
    • PKCCD antibody
    • R74975 antibody
    • zgc:112538 antibody
    • zgc:123320 antibody
    see all

Images

  • All lanes : Anti-CaMKII alpha antibody (ab131468) at 1/500 dilution

    Lane 1 : Extracts from mouse brain tissue
    Lane 2 : Extracts from mouse brain tissue with blocking peptide

    Predicted band size: 54 kDa

  • Immunoflourescent analysis of paraffin-embedded Human hippocampal region tissue from the falling sickness disease labelling CaMKII alpha with ab131468 at 1/100 dilution.

References

This product has been referenced in:

  • Alexander GM  et al. CA2 neuronal activity controls hippocampal low gamma and ripple oscillations. Elife 7:N/A (2018). Read more (PubMed: 30387713) »
  • Lu Y  et al. Intracellular Ca2+ homeostasis and JAK1/STAT3 pathway are involved in the protective effect of propofol on BV2 microglia against hypoxia-induced inflammation and apoptosis. PLoS One 12:e0178098 (2017). WB . Read more (PubMed: 28542400) »
See all 3 Publications for this product

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