The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1000 - 1/10000. Detects a band of approximately 45-70 kDa (predicted molecular weight: 54 kDa).
Use at an assay dependent concentration. PubMed: 24073199
Is unsuitable for ICC,IHC-P or IP.
Function: CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses, it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.
Tissue specificity: Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain.
Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Contains 1 protein kinase domain.
Zhu A et al. Wnt5a mediates chronic post-thoracotomy pain by regulating non-canonical pathways, nerve regeneration, and inflammation in rats. Cell Signal44:51-61 (2018).
Read more (PubMed: 29339085) »
Ahmed ME et al. Beneficial Effects of a CaMKIIa Inhibitor TatCN21 Peptide in Global Cerebral Ischemia. J Mol Neurosci61:42-51 (2017).
Read more (PubMed: 27604243) »