Overview

  • Product name

    Anti-CAMKIV (phospho T200) antibody
    See all CAMKIV primary antibodies
  • Description

    Rabbit polyclonal to CAMKIV (phospho T200)
  • Host species

    Rabbit
  • Specificity

    ab195000 detects endogenous level of CaMKIV only when phosphorylated at threonine196 (mouse) /threonine 200 (human).
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human CAMKIV (phospho T200) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary. [or peptide derived from region around threonine 196 (

    M-K-T(p)-V-C

    ) from Mouse CaMKIV].
    Sequence:

    M-K-T(p)-V-C


    Database link: Q16566

  • Positive control

    • Hydrogen peroxide K562 cell extract.

Properties

Applications

Our Abpromise guarantee covers the use of ab195000 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 52 kDa.

Target

  • Function

    Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. May be involved in transcriptional regulation. May be involved in regulation of microtubule dynamics. In vitro, phosphorylates CREB1, CREBBP, PRM2, MEF2A, MEF2D and STMN1/OP18. May be involved in spermatogenesis. May play a role in the consolidation/retention of hippocampus-dependent long-term memory.
  • Tissue specificity

    Expressed in epithelial ovarian cancer tissue.
  • Sequence similarities

    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications

    Autophosphorylated and phosphorylated by CAMKK1 and CAMKK2 (By similarity). Dephosphorylated by serine/threonine protein phosphatase 2A, probably on Thr-200.
  • Cellular localization

    Cytoplasm. Nucleus. Substantial localization in certain neuronal nuclei. In spermatids associated with chromatin and nuclear matrix.
  • Information by UniProt
  • Database links

  • Alternative names

    • Brain Ca(2+) calmodulin dependent protein kinase type 4 antibody
    • Brain Ca(2+) calmodulin dependent protein kinase type IV antibody
    • Brain Ca++-calmodulin dependent protein kinase type IV antibody
    • Calcium / calmodulin dependent protein kinase type 4 catalytic chain antibody
    • Calcium / calmodulin dependent protein kinase type IV catalytic chain antibody
    • Calcium/calmodulin dependent protein kinase IV antibody
    • Calcium/calmodulin dependent protein kinase type IV antibody
    • Calcium/calmodulin-dependent protein kinase type IV antibody
    • CAM kinase 4 antibody
    • CAM kinase GR antibody
    • CAM kinase IV antibody
    • CAM kinase-GR antibody
    • CaMK 4 antibody
    • CAMK GR antibody
    • CaMK IV antibody
    • Camk4 antibody
    • CaMKGR antibody
    • IV antibody
    • KCC4_HUMAN antibody
    • MGC36771 antibody
    see all

Images

  • All lanes : Anti-CAMKIV (phospho T200) antibody (ab195000) at 1/500 dilution

    Lane 1 : Hydrogen peroxide K562 cell extract
    Lane 2 : Hydrogen peroxide K562 cell extract with antigen-specific peptide

    Predicted band size: 52 kDa

References

ab195000 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab195000.
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