Overview

  • Product name
    Anti-CaMKK antibody - N-terminal
    See all CaMKK primary antibodies
  • Description
    Rabbit polyclonal to CaMKK - N-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    KLH conjugated synthetic peptide selected from the N terminal region of human CaMKK

  • Positive control
    • Mouse cerebellum tissue lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab76534 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/50 - 1/100. Detects a band of approximately 56 kDa (predicted molecular weight: 56 kDa).
ELISA 1/1000.

Target

  • Function
    Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.
  • Sequence similarities
    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
  • Domain
    The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.
    The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates.
  • Post-translational
    modifications
    Appears to be autophosphorylated in a Ca(2+)/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca(2+)/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4.
  • Cellular localization
    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Ca2+/calmodulin-dependent protein kinase kinase alpha antibody
    • Calcium/calmodulin dependent protein kinase kinase antibody
    • Calcium/calmodulin dependent protein kinase kinase 1 alpha antibody
    • Calcium/calmodulin dependent protein kinase kinase 1 antibody
    • Calcium/calmodulin dependent protein kinase kinase alpha antibody
    • Calcium/calmodulin-dependent protein kinase kinase 1 antibody
    • Calcium/calmodulin-dependent protein kinase kinase alpha antibody
    • CaM kinase kinase alpha antibody
    • CaM-kinase IV kinase antibody
    • CaM-kinase kinase 1 antibody
    • CaM-kinase kinase alpha antibody
    • CaM-KK 1 antibody
    • CaM-KK alpha antibody
    • CaMKK 1 antibody
    • CaMKK alpha antibody
    • CAMKK alpha protein antibody
    • CaMKK antibody
    • Camkk1 antibody
    • CAMKKA antibody
    • DKFZp761M0423 antibody
    • KKCC1_HUMAN antibody
    • MGC34095 antibody
    • OTTMUSP00000006419 antibody
    see all

Images

  • Anti-CaMKK antibody - N-terminal (ab76534) at 1/50 dilution + mouse cerebellum tissue lysates at 35 µg

    Predicted band size: 56 kDa
    Observed band size: 56 kDa

References

ab76534 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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