Overview

  • Product name

  • Description

    Rabbit polyclonal to CAMLG/CAML
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Rat, Human
  • Immunogen

    Recombinant fragment corresponding to Rat CAMLG/CAML aa 1-188. Two N-terminal tags, His-tag and GST-tag. Expressed in E. coli.
    Sequence:

    MEPMPSATDGGDRSATPSGLSASQRRAELRRRKLLMNSEQRINRIMGFHR PGSGAEEENQTKSKPLDSDILNPLGVPSVSKRVVLGDSVDGGVTDYQPSG GADIRGAQLGDKLDSFIKAPECSSKDGVELRQRNRGDLTADSAPRGSHHG LEQYLSRFEEAMKLRKQLISEKPSQEDGRTTEEFDSFR


    Database link: Q6DGG9

  • Positive control

    • IHC-P: Rat kidney and cerebrum tissue. WB: Rat liver, cerebrum and testis tissue lysate; Jurkat cell lysate. Recombinant rat CAMLG/CAML protein.
  • General notes

     This product was previously labelled as CAMLG

     

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: PBS, 50% Glycerol
  • Concentration information loading...
  • Purity

    Protein A purified
  • Purification notes

    Antigen-specific affinity chromatography followed by Protein A affinity chromatography
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab231008 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 - 20 µg/ml.
WB Use a concentration of 0.2 - 2 µg/ml.

Target

  • Relevance

    The immunosuppressant drug cyclosporin A blocks a calcium dependent signal from the T cell receptor (TCR) that normally leads to T cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [Entrez Gene]
  • Cellular localization

    Membrane; Multi pass membrane protein.
  • Database links

  • Alternative names

    • calcium modulating cyclophilin ligand antibody
    • calcium modulating ligand antibody
    • Calcium signal modulating cyclophilin ligand antibody
    • CAML antibody
    • cyclophilin B binding protein antibody
    • MGC163197 antibody
    see all

Images

  • DAB stained, formalin-fixed, paraffin-emedded rat cerebrum tissue stained for CAMLG/CAML using ab231008 at 20 µg/mL in immunohistochemical analysis.

  • Anti-CAMLG/CAML antibody (ab231008) at 1 µg/ml + Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate
  • Anti-CAMLG/CAML antibody (ab231008) at 1 µg/ml + Rat testis tissue lysate
  • Anti-CAMLG/CAML antibody (ab231008) at 1 µg/ml + Rat cerebrum tissue lysate
  • Anti-CAMLG/CAML antibody (ab231008) at 1 µg/ml + Rat liver tissue lysate
  • Anti-CAMLG/CAML antibody (ab231008) at 2 µg/ml + Recombinant rat CAMLG/CAML protein
  • DAB stained, formalin-fixed, paraffin-embedded rat kidney tissue stained for CAMLG/CAML using ab231008 at 2µg/mL in immunohistochemical analysis.

References

ab231008 has not yet been referenced specifically in any publications.

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