Cancer cell stemness inhibitor (Napabucasin), high-cancer cell inhibitor (ab145630)

Overview

  • Product name

    Cancer cell stemness inhibitor (Napabucasin), high-cancer cell inhibitor
  • Description

    Potent, broad spectrum stemness high-cancer cell inhibitor
  • Alternative names

    • Napabucasin
  • Biological description

    Potent, broad spectrum stemness high-cancer cell inhibitor (IC50 values are 500 - 1200 nM). Inhibits STAT3-driven gene transcription. Potently prevents self-renewal in cancer stem cells. Shows antineoplastic and antimetastatic effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    83280-65-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Acetylbenzo[f][1]benzofuran-4,9-dione
  • Molecular weight

    240.21
  • Molecular formula

    C14H8O4
  • PubChem identifier

    10331844
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=O)C1=CC2=C(O1)C(=O)C3=CC=CC=C3C2=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Li Y  et al. Suppression of cancer relapse and metastasis by inhibiting cancer stemness. Proc Natl Acad Sci U S A 112:1839-44 (2015). Read more (PubMed: 25605917) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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