Choose from our selection of top quality products for this family of proteins.
For over 30 years B-cell lymphoma-2 (Bcl-2) family have been investigated in cancer research. A subset of proteins in this family (Bcl-2, Bcl -XL, Mcl-1) prevent apoptosis, while others (Bax. Bak, Bad, Bim) trigger the cascades leading to programmed cell death (Figure 1). Thus the activity of the Bcl-2 family members can have huge effects on cell survival, making them desirable therapeutic targets.
See below for a breakdown of the top reagents for this family (including the newly FDA approved Venetoclax), and how they can help you on your research journey.
Figure 1. Interaction of pro-apoptotic Bcl-2 proteins and anti-apoptotic Bcl-2 proteins to modulate apoptosis. Adapted fromClin Cancer Res. 2009 Feb 15;15(4):1126-32. PMID: 19228717.