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The tumor suppressor gene, p53, responds to a range of cellular stresses by functioning as both a transcription factor and inhibitor. Here we discuss the main cellular responses and suggest products for the protein targets involved.
Figure 1: Shows cellular responses mediated by p53 and the protein targets involved. Adapted from doi.org/10.3389/fonc.2014.00285.
p53 can inhibit cell cycle progression in multiple ways: by the upregulation of p21, which in turn inhibits members of the cyclin dependent kinase family, or by the transcriptional regulation of Gadd45 and 14-3-3σ expression.
To explore the different p53 responsive proteins that facilitate cell cycle arrest please see our products below.
|p21||Anti-p21 antibody [EPR362] ||Sorafenib||Recombinant Human p21 protein|
|CDK1||Anti-CDK1 antibody [EPR165]||Ro 3306||Recombinant human CDK1 + CCNB1 protein|
|CDK2||Anti-Cdk2 antibody [E304]||SC 221409||Recombinant human CDK2 + CCNE1 protein|
|CDK3||Anti-Cdk3 antibody||pan kinase: 10Z-Hymenialdisine||Recombinant Human Cdk3 protein|
|CDK4||Anti-Cdk4 antibody [EPR4513-32-7]||Fascaplysin||Recombinant Human Cdk4 protein|
|CDK6||Anti-Cdk6 antibody [EPR4515]||PD0332991||Recombinant human CDK6 + CCND1 protein|
|14-3-3σ||Anti-14-3-3 sigma antibody [EPR5873(2)]||-||Recombinant Human 14-3-3 sigma protein|
p53 plays a role in DNA repair to maintain genomic stability in response to low stress conditions. It can do this via the activation of Gadd45 and p53R2.
To explore these p53 responsive proteins and their role in DNA repair please see our products below.
|Gadd45||Anti-GADD45A antibody||Recombinant Human GADD45A protein||SP600125|
|Anti-GADD45B antibody||Recombinant Human GADD45B protein|
|p53R2||Anti-p53R2 antibody [EPR8816]||Recombinant Human p53R2 protein|
p53 plays a key role in preventing the process of angiogenesis taking place by stimulating the production of a number of genes and inhibiting others. This includes stimulating Tsp1 and BAI1, anti-angiogenic factors; and inhibiting VEGF, a pro-angiogenic factor.
To explore these p53 responsive proteins and their role preventing angiogenesis please see our products below.
|VEGF||Mouse monoclonal [VG-1] to VEGFA||VEGF R2: ZM306416 hydrochloride||Recombinant human VEGF 165A protein (Biotin)||Human VEGF ELISA Kit|
|Natural Human Thrombos-pondin protein||Human Thrombos-pondin 1 ELISA Kit|
|BAI1||Anti-BAI1 antibody||-||Human BAI1 associated protein 2 isoform 3 peptide||-|
p53 stimulates a wide network of signals that act through the extrinsic and intrinsic apoptosis pathways. The extrinsic pathway involves activation of ‘death’ receptors, which leads to the activation of apoptosis- inducing caspases. The intrinsic apoptotic pathway is dominated by the Bcl-2 family of proteins, which also trigger cell death via the common execution caspase cascade.
To explore these p53 responsive proteins and their role in inducing apoptosis please see our products below.
|DR5||Anti-DR5 antibody [EPR1659(2)]||Recombinant Human DR5 protein||Human DR5 ELISA Kit (CD262)||Bioymifi|
|Fas||Anti-Fas antibody [EPR5700]||Recombinant Human Fas Ligand protein||Human Fas Ligand ELISA Kit (APTL)||-|
|Bcl-2||Anti-Bcl-2 antibody [E17]||Recombinant Human Bcl-2 protein||Human Bcl-2 ELISA Kit||Venetoclax ABT -199|
|Bax||Anti-Bax antibody [E63]||Recombinant Human Bax protein||Human Bax ELISA Kit||BAM7|
As an alternative to apoptosis, p53 can induce senescence in response to high levels of stress, thought to be mediated by p53 targets p21 and plasminogen activator inhibitor 1 (PAI-1).
To explore these p53 responsive proteins and their role in senescence please see our products below.
|PAI-1||Anti-PAI1 antibody [EPR17795]||Recombinant human PAI1 protein||Human PAI1 ELISA Kit|