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Evidence suggests that increased ROS levels can play a pivotal role in the generation of the hallmarks of cancer, such as immortilization, cell proliferation, mitogenic signalling, cell survival and the disruption of cell death pathways, angiogenesis and drug resistance. Increased generation of reactive oxygen species and an altered redox status are observed in cancer cells both in vitro and in vivo, with increased ROS stress in cancer cells correlating with increased aggressiveness of tumours and poor prognosis.