For the best experience on the Abcam website please upgrade to a modern browser such as Google Chrome

We use cookies to make our site as useful as possible.

Our Cookie Policy explains how you can opt-out of the cookies we use.

If you continue without changing your cookie settings, we'll assume you’re happy with this.

Continue Continue

United States
Your country/region is currently set to:

If incorrect, please enter your country/region into the box below, to view site information related to your country/region.

Call (888) 77-ABCAM (22226) or contact us
Need help? Contact us

  • My account
  • Sign out
Sign in or Register with us

Welcome

Sign in or

Don't have an account?

Register with us
My basket
Quick order
Abcam homepage

  • Research Products
    By product type
    Primary antibodies
    Secondary antibodies
    ELISA and Matched Antibody Pair Kits
    Cell and tissue imaging tools
    Cellular and biochemical assays
    Proteins and Peptides
    By product type
    Proteomics tools
    Agonists, activators, antagonists and inhibitors
    Cell lines and Lysates
    Multiplex miRNA assays
    Multiplex Assays
    By research area
    Cancer
    Cardiovascular
    Cell Biology
    Epigenetics
    Metabolism
    Developmental Biology
    By research area
    Immunology
    Microbiology
    Neuroscience
    Signal Transduction
    Stem Cells
  • Diagnostic & Therapeutic Solutions
    Custom solutions & partnerships

    Custom antibody development and commercial partnerships to advance your diagnostic and therapeutic discovery.

    Create custom solutions with us

    Partner with us

  • Support
    Support hub

    Access advice and support for any research roadblock

    View support hub

    Protocols

    Your experiments laid out step by step

    View protocols

  • Events
    • Conference calendar
    • Cancer
    • Cardiovascular
    • Epigenetics & Nuclear signaling
    • Immunology
    • Neuroscience
    • Stem cells
    • Tradeshows
    • Scientific webinars
    Keep up to date with the latest events

    Full event breakdown with abstracts, speakers, registration and more

    View global event calendar

  • Pathways
    Cell signalling pathways

    View all pathways

    View all interactive pathways

Supporting our customers and employees during the COVID-19 pandemic. Read more

Tools for immuno-oncology research

Related

  • PD-1/PD-L1 pathway products
    • PD-L1 [28-8] RabMAb® antibody
      • PD1 monoclonal antibody
        • Specific PD-L2 detection
          • Conjugated PD-L1 antibodies
              • Immune identification
                • Immune cell poster
                  • Identify CD8+ T cells
                    • CD4 antibody
                      • Immuno-oncology
                        • Cancer immunotherapy pathway
                          • Cancer immunotherapy and the PD1/PD-L1 pathway
                            • Antibody panels for immune checkpoints
                                • Protocols
                                  • Flow cytometry phenotyping
                                    • Cell staining protocol
                                      • IHC protocol for PD-L1

                                          Everything you need to unlock the power of immuno-oncology biomarkers. 

                                          The immuno-oncology revolution has delivered significant, durable responses for a sub-group of patients. However, these therapies are expensive and associated with side effects, while not ineffective for many. To fully unleash the power of immuno-oncology, new and improved biomarkers are needed that can accurately predict therapeutic responses for larger patient subsets.

                                          To support you in your research to identify and validate immuno-oncology biomarkers, our comprehensive range of flexible and validated research solutions is on hand. Our immuno-oncology range includes products for key immunotherapy targets, including PD-L1, CTLA-4, LAG3 and TIM3.

                                          Take a flexible approach

                                          Our antibodies and assays to immuno-oncology targets are available in multiple formats: whether you are looking for a conjugated recombinant primary antibody, ELISA kit, or BSA-only formulation, search our catalog to find the right format for your research.

                                          Generate data you can trust

                                          To give you specific and reproducible results, our antibodies and assays are supported by extensive data and validation in healthy and diseased tissues and relevant applications. Our immuno-oncology range also includes knockout-validated antibodies for confirmed specificity and CRISPR-engineered knockout cell lines to validate your target or assay function. 


                                          Key products in the range

                                          Here we have highlighted some of our most popular immuno-oncology research antibodies to simplify your selection.

                                          PD-L1

                                          PD-L1 is one of the most well-known immuno-oncology biomarkers. Our knockout-validated PD-L1 [clone 28-8] rabbit recombinant monoclonal antibody is a leader in this space and allows you to investigate PD-L1 across multiple applications in a consistent manner. Showing no cross-reactivity to the highly homologous PD-L2, you can ensure you generate specific and sensitive data.

                                          Figure 1. Knock-out validation results using PD-L1 [28-8] rabbit monoclonal antibody. Left wild type L2987 cells, right PD-L1 KO L2987 cells.
                                          Also in the range:
                                          • Anti-PD-L1 [28-8] conjugated antibodies: Alexa Fluor® 647, Alexa Fluor® 488, Alexa Fluor® 594, Alexa Fluor® 555, and Alexa Fluor® 568  
                                          • Not sure which PD-L1 clone is right for you? Why not try our PD-L1 antibody panel containing multiple clones for easy comparison.


                                          CTLA-4 

                                          CTLA4 was the target of the first immune checkpoint inhibitor antibody for the treatment of cancer. Advance your own CTLA-4 research for the next immunotherapy breakthrough using our range of CTLA-4 reagents.

                                          • Anti-CTLA-4 antibody [SP355] – optimized for use in IHC and flow cytometry
                                          • Anti-CTLA-4 antibody [EPR1476]  – our recombinant RabMAb® tested for use in western blot and ICC. 
                                          • Anti-CTLA4 antibody [EPR1476]  – conjugated with Alexa Fluor® 488 so you can save time and get great fluorescent images. 

                                          PD-1

                                          PD-1 has been targeted with key immuno-oncology drugs, such as ipilimumab and nivolumab. Study this important immune checkpoint protein with our conjugated and unconjugated recombinant primary antibodies.

                                          • Anti-PD-1 antibody [NAT105] – suitable for western blot, flow cytometry, IHC, ICC, and IP
                                          • Alexa Fluor® 647  and Alexa Fluor® 488  conjugated Anti-PD-1 antibodies
                                          • Get the best response by exploring different PD-1 clones with our PD-1 antibody panel.


                                          CXCR4

                                          Activate your immune response and your research with our conjugated and unconjugated antibodies to CXCR4.

                                          • Anti-CXCR4 recombinant rabbit monoclonal antibody [UMB2], knockout validated
                                          • Conjugated recombinant primary antibodies [UMB2]: Alexa Fluor® 647, Alexa Fluor® 568, Alexa Fluor® 488


                                          TNF-alpha

                                          Investigate TNF-alpha in your immuno-oncology research.

                                          • Recombinant anti-TNF-alpha rabbit monoclonal antibody [EPR20972]
                                          • Human TNF-alpha SimpleStep ELISA® kit


                                          TIM-3

                                          Investigate the role of TIM-3 in T-cell exhaustion and examine the potential of this new immuno-oncology target.

                                          • BSA and azide-free unconjugated recombinant TIM-3 antibody is compatible with most assay set-ups and can be consistently produced at scale for all your research and development needs.
                                          • TIM 3 Antibody Panel [EPR22241, CAL69, BLR033F]


                                          LAG-3

                                          Confidently study the immune checkpoint protein LAG-3 with our recombinant antibodies available with a variety of conjugates or use our antibody panel which contains six recombinant monoclonal antibodies to human LAG-3. 

                                          • Alexa Fluor 647 or Alexa Fluor 488 conjugated recombinant primary Anti-LAG3 antibodies
                                          • LAG-3 Antibody Panel [EPR20261, EPR4392(2), SP346, CAL77, CAL25, CAL26]

                                          ​

                                          Can't see what you need? Whatever immuno-oncology target you are investigating, find the products you need in our extensive catalog. 

                                          Find out in this application note how you can carry out immuno-oncology biomarker measurement with high sensitivity and speed using SimpleStep ELISA® kits and SPECTROstar®Nano

                                          ​See the full immuno-oncology ELISA kit brochure here


                                          Alexa Fluor® is a registered trademark of Life Technologies. Alexa Fluor® dye conjugates contain(s) technology licensed to Abcam by Life Technologies.


                                          Get resources and offers direct to your inbox Sign up
                                          A-Z by research area
                                          • Cancer
                                          • Cardiovascular
                                          • Cell biology
                                          • Developmental biology
                                          • Epigenetics & Nuclear signaling
                                          • Immunology
                                          • Metabolism
                                          • Microbiology
                                          • Neuroscience
                                          • Signal transduction
                                          • Stem cells
                                          A-Z by product type
                                          • Primary antibodies
                                          • Secondary antibodies
                                          • Biochemicals
                                          • Isotype controls
                                          • Flow cytometry multi-color selector
                                          • Kits
                                          • Loading controls
                                          • Lysates
                                          • Peptides
                                          • Proteins
                                          • Slides
                                          • Tags and cell markers
                                          • Tools & Reagents
                                          Help & support
                                          • Support
                                          • Make an Inquiry
                                          • Protocols & troubleshooting
                                          • Placing an order
                                          • RabMAb products
                                          • Biochemical product FAQs
                                          • Training
                                          • Browse by Target
                                          Company
                                          • Corporate site
                                          • Investor relations
                                          • Company news
                                          • Careers
                                          • About us
                                          • Blog
                                          Events
                                          • Tradeshows
                                          • Conferences
                                          International websites
                                          • abcam.cn
                                          • abcam.co.jp

                                          Join with us

                                          • LinkedIn
                                          • facebook
                                          • Twitter
                                          • YouTube
                                          • Terms of sale
                                          • Website terms of use
                                          • Cookie policy
                                          • Privacy policy
                                          • Legal
                                          • Modern slavery statement
                                          © 1998-2021 Abcam plc. All rights reserved.