Tools for immuno-oncology research
Related
Everything you need to unlock the power of immuno-oncology biomarkers.
The immuno-oncology revolution has delivered significant, durable responses for a sub-group of patients. However, these therapies are expensive and associated with side effects, while not ineffective for many. To fully unleash the power of immuno-oncology, new and improved biomarkers are needed that can accurately predict therapeutic responses for larger patient subsets.
To support you in your research to identify and validate immuno-oncology biomarkers, our comprehensive range of flexible and validated research solutions is on hand. Our immuno-oncology range includes products for key immunotherapy targets, including PD-L1, CTLA-4, LAG3 and TIM3.
Take a flexible approach
Our antibodies and assays to immuno-oncology targets are available in multiple formats: whether you are looking for a conjugated recombinant primary antibody, ELISA kit, or BSA-only formulation, search our catalog to find the right format for your research.
Generate data you can trust
To give you specific and reproducible results, our antibodies and assays are supported by extensive data and validation in healthy and diseased tissues and relevant applications. Our immuno-oncology range also includes knockout-validated antibodies for confirmed specificity and CRISPR-engineered knockout cell lines to validate your target or assay function.
Key products in the range
Here we have highlighted some of our most popular immuno-oncology research antibodies to simplify your selection.
PD-L1
PD-L1 is one of the most well-known immuno-oncology biomarkers. Our knockout-validated PD-L1 [clone 28-8] rabbit recombinant monoclonal antibody is a leader in this space and allows you to investigate PD-L1 across multiple applications in a consistent manner. Showing no cross-reactivity to the highly homologous PD-L2, you can ensure you generate specific and sensitive data.
Figure 1. Knock-out validation results using PD-L1 [28-8] rabbit monoclonal antibody. Left wild type L2987 cells, right PD-L1 KO L2987 cells.
Also in the range:
- Anti-PD-L1 [28-8] conjugated antibodies: Alexa Fluor® 647, Alexa Fluor® 488, Alexa Fluor® 594, Alexa Fluor® 555, and Alexa Fluor® 568
- Not sure which PD-L1 clone is right for you? Why not try our PD-L1 antibody panel containing multiple clones for easy comparison.
CTLA-4
CTLA4 was the target of the first immune checkpoint inhibitor antibody for the treatment of cancer. Advance your own CTLA-4 research for the next immunotherapy breakthrough using our range of CTLA-4 reagents.
- Anti-CTLA-4 antibody [SP355] – optimized for use in IHC and flow cytometry
- Anti-CTLA-4 antibody [EPR1476] – our recombinant RabMAb® tested for use in western blot and ICC.
- Anti-CTLA4 antibody [EPR1476] – conjugated with Alexa Fluor® 488 so you can save time and get great fluorescent images.
PD-1
PD-1 has been targeted with key immuno-oncology drugs, such as ipilimumab and nivolumab. Study this important immune checkpoint protein with our conjugated and unconjugated recombinant primary antibodies.
- Anti-PD-1 antibody [NAT105] – suitable for western blot, flow cytometry, IHC, ICC, and IP
- Alexa Fluor® 647 and Alexa Fluor® 488 conjugated Anti-PD-1 antibodies
- Get the best response by exploring different PD-1 clones with our PD-1 antibody panel.
CXCR4
Activate your immune response and your research with our conjugated and unconjugated antibodies to CXCR4.
- Anti-CXCR4 recombinant rabbit monoclonal antibody [UMB2], knockout validated
- Conjugated recombinant primary antibodies [UMB2]: Alexa Fluor® 647, Alexa Fluor® 568, Alexa Fluor® 488
TNF-alpha
Investigate TNF-alpha in your immuno-oncology research.
- Recombinant anti-TNF-alpha rabbit monoclonal antibody [EPR20972]
- Human TNF-alpha SimpleStep ELISA® kit
TIM-3
Investigate the role of TIM-3 in T-cell exhaustion and examine the potential of this new immuno-oncology target.
- BSA and azide-free unconjugated recombinant TIM-3 antibody is compatible with most assay set-ups and can be consistently produced at scale for all your research and development needs.
LAG-3
Confidently study the immune checkpoint protein LAG-3 with our recombinant antibodies available with a variety of conjugates or use our antibody panel which contains six recombinant monoclonal antibodies to human LAG-3.
- Alexa Fluor 647 or Alexa Fluor 488 conjugated recombinant primary Anti-LAG3 antibodies
Can't see what you need? Whatever immuno-oncology target you are investigating, find the products you need in our extensive catalog.
See the full immuno-oncology ELISA kit brochure here
Alexa Fluor® is a registered trademark of Life Technologies. Alexa Fluor® dye conjugates contain(s) technology licensed to Abcam by Life Technologies.