Overview

  • Product name

    Canertinib (CI-1033), EGFR and HER2/ErbB2 tyrosine kinase inhibitor
  • Description

    Potent irreversible EGFR and HER2/ErbB2 tyrosine kinase inhibitor
  • Alternative names

    • CI-1033
  • Biological description

    Potent, irreversible pan-ErbB tyrosine kinase inhibitor (IC50 values are 1.5 and 9 nM at EGFR and ErbB2 respectively). Orally active. Antitumor and radiation-sensitizing agent. Active in vivo and in vitro.
  • Purity

    > 99%
  • CAS Number

    289499-45-2
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Djerf Severinsson EA  et al. The pan-ErbB receptor tyrosine kinase inhibitor canertinib promotes apoptosis of malignant melanoma in vitro and displays anti-tumor activity in vivo. Biochem Biophys Res Commun 414:563-8 (2011). Read more (PubMed: 21982771) »
  • Nyati MK  et al. Radiosensitization by pan ErbB inhibitor CI-1033 in vitro and in vivo. Clin Cancer Res 10:691-700 (2004). Read more (PubMed: 14760092) »
  • Smaill JB  et al. Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions. J Med Chem 43:1380-97 (2000). Read more (PubMed: 10753475) »

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