Overview

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab50542 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Cannabinoid Receptor I antibody (ab23703)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline, pH 7.4

General Info

  • Alternative names
    • CANN6
    • Cannabinoid receptor 1
    • CB-R
    • CB1
    • CB1A
    • CB1K5
    • CB1R
    • Central cannabinoid receptor
    • CNR
    • CNR1
    • CNR1_HUMAN
    • OTTHUMP00000016838
    • OTTHUMP00000214579
    see all
  • Function
    Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.
  • Tissue specificity
    Widely expressed.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization
    Cell membrane.
  • Information by UniProt

References

This product has been referenced in:
  • Jang JH  et al. Novel analgesic effects of melanin-concentrating hormone on persistent neuropathic and inflammatory pain in mice. Sci Rep 8:707 (2018). Read more (PubMed: 29335480) »
  • Gustafsson SB  et al. High Tumour Cannabinoid CB(1) Receptor Immunoreactivity Negatively Impacts Disease-Specific Survival in Stage II Microsatellite Stable Colorectal Cancer. PLoS One 6:e23003 (2011). Read more (PubMed: 21901119) »
See all 6 Publications for this product

Customer reviews and Q&As

1-2 of 2 Abreviews or Q&A

Answer

Thank you for your enquiry.

I can confirm that this peptide has been designed as an immunogen for Cannabinoid Receptor I antibody ab23703. It can be used as a blocking peptide with this antibody. I am sorry wee have no data to show that the peptide is suitable for study of the kinetics with chemical agents, small molecules, and therefore we are regrettaby not able to guarantee it for this purpose.

There may be information of interest to you in the following link:
http://scholar.google.com/scholar?q=CB1+Receptor+%28C-Term%29+Blocking+Peptide+and+kinetics&btnG=&hl=en&as_sdt=0%2C23

Molecular structure and function of 7TM/G-protein coupled receptors
TW Schwartz, B Holst - Textbook of receptor pharmacology, 2002 - books.google.com
... In the MSH/adrenocorticotrophic hormone (ACTH) and the cannabinoid CB1 and CB2 receptors, this disulfide bridge is absent ... mrw., V N-term 1C 1 EC 1 IC 2 EC 2A EC 2B 1C 3 EC 3 C-term 100 50 N-term EC1 EC EC 2A2B peptide receptors ic 1 EC 3 IC2 IC 3 C-term N-term ...

TREK-1 and Best1 Channels Mediate Fast and Slow Glutamate Release in Astrocytes upon GPCR Activation
DH Woo, KS Han, JW Shim, BE Yoon, E Kim, JY Bae… - Cell, 2012 - Elsevier
... In the presence of astrocyte buffer without TFLLR or RLLFT, a reverse peptide of TFLLR never caused a sensor current (Figures S1 ... and β-ARK-c term. ... G and H) The agonists of Gi-coupled GPCRs such as adenosine 1 receptor (A1R) and cannabinoid 1 receptor (CB1) induce a ...

G‐Protein‐Coupled Receptors
SL Garland, TD Heightman - Gene Family Targeted Molecular …, 2008 - books.google.com
... Coexpression of both CB1 and Ox-1 in CHO cells yields a 100-fold greater ... GPCR STRUCTURE AND FUNCTION 29 such as receptor internalization, recycling, and the strength of activation of ... spanning region of around 22 residues, and ending with a small C-term of around 10 ...
[PDF] from columbia.edu

Deconstructing G Protein-Coupled Receptor Dimer Pharmacology: Case Studies in Dopamine D1 and D2 Receptors
H Yano - 2012 - academiccommons.columbia.edu
... proteins, various extracellular signals (eg light, neurotransmitters, peptide hormones, and ... the receptor in a certain conformation amenable to better ligand binding. Another important ... differences in the kinetics of Gs-dependent signaling were shown between adenosine A2A ...

DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF POTENTIAL INHIBITORS OF PILUS ASSEMBLY IN PATHOGENIC BACTERIA. AS SSR182289A, POAT INHIBITOR - journals.prous.com
... Pilicides designed from PapG C-term (1). 2-Pyridinones (2), Penams (3) and amino acid ... b-LABs act by blocking the growth of the peptidoglican, through the binding to a ... in an in vitro cellular assay, which showed increased insulin-stimulated insulin receptor phosphorylation. ...

I hope this will be helpful to you. If you have any further questions, please do not hesitate to contact us.

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Question
Answer

This 12 amino acid peptide immunogen has a molecular weight of 1,211.3 Da.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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