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  1. Link

    cannabinoid-receptor-i-peptide-ab50542.pdf

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Neuroscience Neurotransmission Receptors / Channels GPCR Cannabinoid Receptor
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Cannabinoid Receptor I peptide (ab50542)

  • Datasheet
  • SDS
Submit a review Q&A (2)References (7)

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Abpromise

Guaranteed product quality, expert customer support.

Find out more.

Key features and details

  • Suitable for: Blocking

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Anti-Cannabinoid Receptor I antibody (ab23703)

View more associated products

Description

  • Product name

    Cannabinoid Receptor I peptide
    See all Cannabinoid Receptor I proteins and peptides
  • Animal free

    No
  • Nature

    Synthetic

Associated products

  • Corresponding Antibody

    • Anti-Cannabinoid Receptor I antibody (ab23703)

Specifications

Our Abpromise guarantee covers the use of ab50542 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Cannabinoid Receptor I antibody (ab23703)

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: 0.1% BSA, Tris buffered saline

General Info

  • Alternative names

    • CANN6
    • Cannabinoid receptor 1
    • CB-R
    • CB1
    • CB1A
    • CB1K5
    • CB1R
    • Central cannabinoid receptor
    • CNR
    • CNR1
    • CNR1_HUMAN
    • OTTHUMP00000016838
    • OTTHUMP00000214579
    see all
  • Function

    Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.
  • Tissue specificity

    Widely expressed.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization

    Cell membrane.
  • Target information above from: UniProt accession P21554 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download

References (7)

Publishing research using ab50542? Please let us know so that we can cite the reference in this datasheet.

ab50542 has been referenced in 7 publications.

  • Nielsen JE  et al. Characterisation and localisation of the endocannabinoid system components in the adult human testis. Sci Rep 9:12866 (2019). PubMed: 31537814
  • Jang JH  et al. Novel analgesic effects of melanin-concentrating hormone on persistent neuropathic and inflammatory pain in mice. Sci Rep 8:707 (2018). PubMed: 29335480
  • Gustafsson SB  et al. High Tumour Cannabinoid CB(1) Receptor Immunoreactivity Negatively Impacts Disease-Specific Survival in Stage II Microsatellite Stable Colorectal Cancer. PLoS One 6:e23003 (2011). PubMed: 21901119
  • Björklund E  et al. Increased Expression of Cannabinoid CB(1) Receptors in Achilles Tendinosis. PLoS One 6:e24731 (2011). Blocking . PubMed: 21931835
  • Zurolo E  et al. CB1 and CB2 cannabinoid receptor expression during development and in epileptogenic developmental pathologies. Neuroscience 170:28-41 (2010). IHC-P, Blocking . PubMed: 20621164
  • Tyagi V  et al. Differential expression of functional cannabinoid receptors in human bladder detrusor and urothelium. J Urol 181:1932-8 (2009). WB, Blocking . PubMed: 19237176
  • Horne AW  et al. CB1 expression is attenuated in Fallopian tube and decidua of women with ectopic pregnancy. PLoS ONE 3:e3969 (2008). Blocking, IHC-Fr . PubMed: 19093002

Customer reviews and Q&As

Show All Reviews Q&A
Submit a review Submit a question

1-2 of 2 Abreviews or Q&A

Question

Inquiry: Hello. I have such question: Is this peptide (human cannabinoid receptor I peptide) suitable for study kinetics of binding this peptide with chemical agent (small molecule)? If not, what can you advise? I plan to use Biacore apparatus .

Read More

Abcam community

Verified customer

Asked on Dec 27 2012

Answer

Thank you for your enquiry.

I can confirm that this peptide has been designed as an immunogen for Cannabinoid Receptor I antibody ab23703. It can be used as a blocking peptide with this antibody. I am sorry wee have no data to show that the peptide is suitable for study of the kinetics with chemical agents, small molecules, and therefore we are regrettaby not able to guarantee it for this purpose.

There may be information of interest to you in the following link:
http://scholar.google.com/scholar?q=CB1+Receptor+%28C-Term%29+Blocking+Peptide+and+kinetics&btnG=&hl=en&as_sdt=0%2C23

Molecular structure and function of 7TM/G-protein coupled receptors
TW Schwartz, B Holst - Textbook of receptor pharmacology, 2002 - books.google.com
... In the MSH/adrenocorticotrophic hormone (ACTH) and the cannabinoid CB1 and CB2 receptors, this disulfide bridge is absent ... mrw., V N-term 1C 1 EC 1 IC 2 EC 2A EC 2B 1C 3 EC 3 C-term 100 50 N-term EC1 EC EC 2A2B peptide receptors ic 1 EC 3 IC2 IC 3 C-term N-term ...

TREK-1 and Best1 Channels Mediate Fast and Slow Glutamate Release in Astrocytes upon GPCR Activation
DH Woo, KS Han, JW Shim, BE Yoon, E Kim, JY Bae… - Cell, 2012 - Elsevier
... In the presence of astrocyte buffer without TFLLR or RLLFT, a reverse peptide of TFLLR never caused a sensor current (Figures S1 ... and β-ARK-c term. ... G and H) The agonists of Gi-coupled GPCRs such as adenosine 1 receptor (A1R) and cannabinoid 1 receptor (CB1) induce a ...

G‐Protein‐Coupled Receptors
SL Garland, TD Heightman - Gene Family Targeted Molecular …, 2008 - books.google.com
... Coexpression of both CB1 and Ox-1 in CHO cells yields a 100-fold greater ... GPCR STRUCTURE AND FUNCTION 29 such as receptor internalization, recycling, and the strength of activation of ... spanning region of around 22 residues, and ending with a small C-term of around 10 ...
[PDF] from columbia.edu

Deconstructing G Protein-Coupled Receptor Dimer Pharmacology: Case Studies in Dopamine D1 and D2 Receptors
H Yano - 2012 - academiccommons.columbia.edu
... proteins, various extracellular signals (eg light, neurotransmitters, peptide hormones, and ... the receptor in a certain conformation amenable to better ligand binding. Another important ... differences in the kinetics of Gs-dependent signaling were shown between adenosine A2A ...

DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF POTENTIAL INHIBITORS OF PILUS ASSEMBLY IN PATHOGENIC BACTERIA. AS SSR182289A, POAT INHIBITOR - journals.prous.com
... Pilicides designed from PapG C-term (1). 2-Pyridinones (2), Penams (3) and amino acid ... b-LABs act by blocking the growth of the peptidoglican, through the binding to a ... in an in vitro cellular assay, which showed increased insulin-stimulated insulin receptor phosphorylation. ...

I hope this will be helpful to you. If you have any further questions, please do not hesitate to contact us.

Read More

Abcam Scientific Support

Answered on Dec 27 2012

Question

What is the molecular weight of this peptide?

Read More

Abcam community

Verified customer

Asked on Oct 09 2012

Answer

This 12 amino acid peptide immunogen has a molecular weight of 1,211.3 Da.

Read More

Abcam Scientific Support

Answered on Oct 09 2012

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