Anti-Cannabinoid Receptor II antibody (ab150569)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cannabinoid Receptor II antibody (ab150569)

    Key features and details

    • Rabbit polyclonal to Cannabinoid Receptor II
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

    Overview

    • Product name

      Anti-Cannabinoid Receptor II antibody
      See all Cannabinoid Receptor II primary antibodies

    • Description

      Rabbit polyclonal to Cannabinoid Receptor II

    • Host species

      Rabbit

    • Specificity

      BLAST analysis of the peptide immunogen showed no homology with other human proteins.

    • Tested applications

      Suitable for: IHC-Pmore details

    • Species reactivity

      Reacts with: Human
      Predicted to work with: Monkey, Gorilla, Common marmoset, Elephant

    • Immunogen

      Synthetic peptide corresponding to Human Cannabinoid Receptor II (N terminal). A 20 amino acid synthetic peptide from the N-terminal extracellular domain of Human Cannabinoid Receptor II.
      Database link: P34972

    • Positive control

      • Human tonsil tissue.

    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab150569 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    IHC-P
    Use a concentration of 17 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
    Notes
    IHC-P
    Use a concentration of 17 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

    Target

    • Function

      Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.

    • Tissue specificity

      Preferentially expressed in cells of the immune system with higher expression in B cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root glanglion sensory neurons (at protein level).

    • Sequence similarities

      Belongs to the G-protein coupled receptor 1 family.

    • Post-translational
      modifications

      Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.

    • Cellular localization

      Cell membrane. Cell projection > dendrite. Perikaryon. Localizes to apical dendrite of pyramidal neurons.
    • Information by UniProt

    • Database links

      • Alternative names

        • Cannabinoid receptor 2 antibody
        • Cannabinoid receptor 2 macrophage antibody
        • CB 2 antibody
        • CB-2 antibody
        • CB2 antibody
        • CNR2 antibody
        • CNR2_HUMAN antibody
        • CNRII antibody
        • CX 5 antibody
        • CX5 antibody
        • hCB2 antibody
        • testis-dominant CNR2 isoform CB2 antibody
        see all

      Images

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cannabinoid Receptor II antibody (ab150569)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cannabinoid Receptor II antibody (ab150569)
        Immunohistochemical analysis of formalin fixed and paraffin embedded Human tonsil tissue, germinal center and mantle zone labelling Cannabinoid Receptor II with ab150569 at 17 ug/ml after heat-induced antigen retrieval.

      References (0)

      Publishing research using ab150569? Please let us know so that we can cite the reference in this datasheet.

      ab150569 has not yet been referenced specifically in any publications.

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