Key features and details
- Rabbit polyclonal to Cannabinoid Receptor II
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Cannabinoid Receptor II antibody
See all Cannabinoid Receptor II primary antibodies
DescriptionRabbit polyclonal to Cannabinoid Receptor II
SpecificityBLAST analysis of the peptide immunogen showed no homology with other human proteins.
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Monkey, Gorilla, Common marmoset, Elephant
Synthetic peptide corresponding to Human Cannabinoid Receptor II (N terminal). A 20 amino acid synthetic peptide from the N-terminal extracellular domain of Human Cannabinoid Receptor II.
Database link: P34972
- Human tonsil tissue.
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We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C.
Storage bufferPreservative: 0.1% Sodium azide
Constituent: 99.9% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab150569 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 17 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.|
FunctionHeterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
Tissue specificityPreferentially expressed in cells of the immune system with higher expression in B cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root glanglion sensory neurons (at protein level).
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
modificationsConstitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.
Cellular localizationCell membrane. Cell projection > dendrite. Perikaryon. Localizes to apical dendrite of pyramidal neurons.
- Information by UniProt
- Cannabinoid receptor 2 antibody
- Cannabinoid receptor 2 macrophage antibody
- CB 2 antibody
ab150569 has not yet been referenced specifically in any publications.