Anti-Cannabinoid Receptor II antibody (ab150569)
- Datasheet
- References
- Protocols
Overview
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Product name
Anti-Cannabinoid Receptor II antibody
See all Cannabinoid Receptor II primary antibodies -
Description
Rabbit polyclonal to Cannabinoid Receptor II -
Host species
Rabbit -
Specificity
BLAST analysis of the peptide immunogen showed no homology with other human proteins. -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Monkey, Gorilla, Common marmoset, Elephant
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Immunogen
Synthetic peptide corresponding to Human Cannabinoid Receptor II (N terminal). A 20 amino acid synthetic peptide from the N-terminal extracellular domain of Human Cannabinoid Receptor II.
Database link: P34972 -
Positive control
- Human tonsil tissue.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. -
Storage buffer
Preservative: 0.1% Sodium azide
Constituent: 99.9% PBS -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab150569 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | Use a concentration of 17 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. |
Target
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Function
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. -
Tissue specificity
Preferentially expressed in cells of the immune system with higher expression in B cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root glanglion sensory neurons (at protein level). -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Post-translational
modificationsConstitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor. -
Cellular localization
Cell membrane. Cell projection > dendrite. Perikaryon. Localizes to apical dendrite of pyramidal neurons. - Information by UniProt
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Database links
- Entrez Gene: 1269 Human
- Omim: 605051 Human
- SwissProt: P34972 Human
- Unigene: 73037 Human
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Alternative names
- Cannabinoid receptor 2 antibody
- Cannabinoid receptor 2 macrophage antibody
- CB 2 antibody
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Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cannabinoid Receptor II antibody (ab150569)Immunohistochemical analysis of formalin fixed and paraffin embedded Human tonsil tissue, germinal center and mantle zone labelling Cannabinoid Receptor II with ab150569 at 17 ug/ml after heat-induced antigen retrieval.
Protocols
References
ab150569 has not yet been referenced specifically in any publications.
