Overview

  • Product name

    Anti-Cannabinoid Receptor II antibody
    See all Cannabinoid Receptor II primary antibodies
  • Description

    Rabbit polyclonal to Cannabinoid Receptor II
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Dog
  • Immunogen

    Synthetic peptide corresponding to Human Cannabinoid Receptor II. 20 amino acid peptide from 3rd cytoplasmic domain of human Cannabinoid Receptor II.
    Database link: P34972

  • Positive control

    • IHC-P: Human glioblastoma, tonsil, skin melanoma, breast carcinoma and pancreas carcinoma tissue.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.099% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab230791 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 13 - 26 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
  • Tissue specificity

    Preferentially expressed in cells of the immune system with higher expression in B cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root glanglion sensory neurons (at protein level).
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Post-translational
    modifications

    Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.
  • Cellular localization

    Cell membrane. Cell projection > dendrite. Perikaryon. Localizes to apical dendrite of pyramidal neurons.
  • Information by UniProt
  • Database links

  • Alternative names

    • Cannabinoid receptor 2 antibody
    • Cannabinoid receptor 2 macrophage antibody
    • CB 2 antibody
    • CB-2 antibody
    • CB2 antibody
    • CNR2 antibody
    • CNR2_HUMAN antibody
    • CNRII antibody
    • CX 5 antibody
    • CX5 antibody
    • hCB2 antibody
    • testis-dominant CNR2 isoform CB2 antibody
    see all

Images

  • Formalin-fixed, paraffin-embedded human glioblastoma tissue stained for Cannabinoid Receptor II with ab230791 at 26 μg/ml in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human tonsil tissue stained for Cannabinoid Receptor II with ab230791 at 26 μg/ml in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human skin melanoma tissue stained for Cannabinoid Receptor II with ab230791 at 26 μg/ml in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human breast carcinoma tissue stained for Cannabinoid Receptor II with ab230791 at 26 μg/ml in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human pancreas carcinoma tissue stained for Cannabinoid Receptor II with ab230791 at 26 μg/ml in immunohistochemical analysis.

References

ab230791 has not yet been referenced specifically in any publications.

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