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    cannabinoid-receptor-ii-peptide-ab45941.pdf

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Neuroscience Neurotransmission Receptors / Channels GPCR Cannabinoid Receptor
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Cannabinoid Receptor II peptide (ab45941)

  • Datasheet
Submit a review Submit a question References (5)

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Promotion Information

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Key features and details

  • Purity: > 90% HPLC
  • Suitable for: Blocking, WB

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Recombinant Human Cannabinoid Receptor I protein (ab158150)
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Anti-Cannabinoid Receptor II antibody (ab3561)
Peptide
Cannabinoid Receptor I peptide (ab50542)

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Description

  • Product name

    Cannabinoid Receptor II peptide
    See all Cannabinoid Receptor II proteins and peptides
  • Purity

    > 90 % HPLC.

  • Accession

    P34972
  • Animal free

    No
  • Nature

    Synthetic
    • Species

      Human
  • Description

    Human Cannabinoid Receptor II peptide

Specifications

Our Abpromise guarantee covers the use of ab45941 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

    Western blot

  • Form

    Lyophilized
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C.

    Information available upon request.

General Info

  • Alternative names

    • Cannabinoid receptor 2
    • Cannabinoid receptor 2 macrophage
    • CB 2
    • CB-2
    • CB2
    • CNR2
    • CNR2_HUMAN
    • CNRII
    • CX 5
    • CX5
    • hCB2
    • testis-dominant CNR2 isoform CB2
    see all
  • Function

    Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
  • Tissue specificity

    Preferentially expressed in cells of the immune system with higher expression in B cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root glanglion sensory neurons (at protein level).
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Post-translational
    modifications

    Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.
  • Cellular localization

    Cell membrane. Cell projection > dendrite. Perikaryon. Localizes to apical dendrite of pyramidal neurons.
  • Target information above from: UniProt accession P34972 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • Datasheet download

    Download

References (5)

Publishing research using ab45941? Please let us know so that we can cite the reference in this datasheet.

ab45941 has been referenced in 5 publications.

  • Lah TT  et al. Cannabigerol Is a Potential Therapeutic Agent in a Novel Combined Therapy for Glioblastoma. Cells 10:N/A (2021). PubMed: 33562819
  • Ghosh S  et al. The Endocannabinoid/Cannabinoid Receptor 2 System Protects Against Cisplatin-Induced Hearing Loss. Front Cell Neurosci 12:271 (2018). PubMed: 30186120
  • Martín-Saldaña S  et al. Spontaneous Cannabinoid Receptor 2 (CB2) Expression in the Cochlea of Adult Albino Rat and Its Up-Regulation after Cisplatin Treatment. PLoS One 11:e0161954 (2016). PubMed: 27564061
  • den Boon FS  et al. Excitability of prefrontal cortical pyramidal neurons is modulated by activation of intracellular type-2 cannabinoid receptors. Proc Natl Acad Sci U S A 109:3534-9 (2012). WB . PubMed: 22331871
  • Tyagi V  et al. Differential expression of functional cannabinoid receptors in human bladder detrusor and urothelium. J Urol 181:1932-8 (2009). WB . PubMed: 19237176

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