Overview

  • Product name

    Cantharidic acid, PP2A and PP1 inhibitor
  • Description

    Potent, selective PP2A and PP1 inhibitor
  • Biological description

    Potent, selective PP2A and PP1 inhibitor (IC50 values are 50 nM and 562 nM respectively). Anti-apoptotic agent. Enhances adenovirus transduction efficiency in vitro.
  • Purity

    > 98%
  • CAS Number

    28874-45-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1R,2S,3R,4S)-2,3-Dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid
  • Molecular weight

    214.20
  • Molecular formula

    C10H14O5
  • PubChem identifier

    121475
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 25 mM (with warming)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1(C2CCC(C1(C)C(=O)O)O2)C(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Cayer MP  et al. Suppression of protein phosphatase 2A activity enhances Ad5/F35 adenovirus transduction efficiency in normal human B lymphocytes and in Raji cells. J Immunol Methods 376:113-24 (2012). Read more (PubMed: 22210093) »
  • Schweyer S  et al. Expression and function of protein phosphatase PP2A in malignant testicular germ cell tumours. J Pathol 213:72-81 (2007). Read more (PubMed: 17590861) »
  • Li YM & Casida JE Cantharidin-binding protein: identification as protein phosphatase 2A. Proc Natl Acad Sci U S A 89:11867-70 (1992). Read more (PubMed: 1334551) »

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