Anti-Capicua/CIC antibody (ab123822)
Key features and details
- Rabbit polyclonal to Capicua/CIC
- Suitable for: WB, IP
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Capicua/CIC antibody -
Description
Rabbit polyclonal to Capicua/CIC -
Host species
Rabbit -
Tested applications
Suitable for: WB, IPmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Rabbit, Dog, Chimpanzee, Rhesus monkey, Bat -
Immunogen
Synthetic peptide within Human Capicua/CIC aa 1500 to the C-terminus (C terminal). The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements. NP_055940.3
Database link: Q96RK0 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7
Preservative: 0.09% Sodium azide
Constituent: Tris citrate/phosphate -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab123822 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB | (1) |
Use at an assay dependent concentration.
|
IP |
Use at an assay dependent concentration.
|
Notes |
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WB
Use at an assay dependent concentration. |
IP
Use at an assay dependent concentration. |
Target
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Function
Transcriptional repressor which may play a role in development of the central nervous system (CNS). -
Tissue specificity
Expressed in fetal brain. -
Sequence similarities
Contains 1 HMG box DNA-binding domain. -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 23152 Human
- Omim: 612082 Human
- SwissProt: Q96RK0 Human
- Unigene: 388236 Human
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Alternative names
- Capicua homolog (Drosophila) antibody
- Cic antibody
- CIC_HUMAN antibody
see all
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (6)
ab123822 has been referenced in 6 publications.
- Bunda S et al. c-Src Phosphorylates and Inhibits the Function of the CIC Tumor Suppressor Protein. Mol Cancer Res 18:774-786 (2020). PubMed: 32029440
- Chopra R et al. Altered Capicua expression drives regional Purkinje neuron vulnerability through ion channel gene dysregulation in spinocerebellar ataxia type 1. Hum Mol Genet 29:3249-3265 (2020). PubMed: 32964235
- Bunda S et al. CIC protein instability contributes to tumorigenesis in glioblastoma. Nat Commun 10:661 (2019). PubMed: 30737375
- Miao LJ et al. miR-106b promotes proliferation and invasion by targeting Capicua through MAPK signaling in renal carcinoma cancer. Onco Targets Ther 12:3595-3607 (2019). PubMed: 31190862
- Rousseaux MWC et al. ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism. Neuron 97:1235-1243.e5 (2018). PubMed: 29526553
- Simón-Carrasco L et al. Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma. Genes Dev 31:1456-1468 (2017). PubMed: 28827401