Key features and details
- Rabbit polyclonal to Capicua/CIC
- Suitable for: WB, IP
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Capicua/CIC antibody
DescriptionRabbit polyclonal to Capicua/CIC
Tested applicationsSuitable for: WB, IPmore details
Species reactivityReacts with: Human
Predicted to work with: Rabbit, Dog, Chimpanzee, Rhesus monkey, Bat
Other Immunogen Type corresponding to Capicua/CIC. (GeneID 23152)
Database link: NP_055940.3
This product was previously labelled as Capicua
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.09% Sodium azide
Constituent: Tris citrate/phosphate
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab123822 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use at an assay dependent concentration.|
|IP||Use at an assay dependent concentration.|
FunctionTranscriptional repressor which may play a role in development of the central nervous system (CNS).
Tissue specificityExpressed in fetal brain.
Sequence similaritiesContains 1 HMG box DNA-binding domain.
- Information by UniProt
- Capicua homolog (Drosophila) antibody
- Cic antibody
- CIC_HUMAN antibody
ab123822 has been referenced in 4 publications.
- Bunda S et al. CIC protein instability contributes to tumorigenesis in glioblastoma. Nat Commun 10:661 (2019). PubMed: 30737375
- Miao LJ et al. miR-106b promotes proliferation and invasion by targeting Capicua through MAPK signaling in renal carcinoma cancer. Onco Targets Ther 12:3595-3607 (2019). PubMed: 31190862
- Rousseaux MWC et al. ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism. Neuron 97:1235-1243.e5 (2018). PubMed: 29526553
- Simón-Carrasco L et al. Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma. Genes Dev 31:1456-1468 (2017). PubMed: 28827401