Product nameCapreomycin sulfate, peptide antibiotic
DescriptionCyclic peptide antibiotic belonging to the tuberactinomycin family of antibiotics.
- Capreomycin sulfate salt
Cyclic peptide antibiotic thought to inhibit protein synthesis by binding to the 70S ribosomal unit. Disrupts interaction of Mycobacterium tuberculosis ribosomal proteins L12 and L10. Tuberactinomycin antibiotic given in combination with other antibiotics for multidrug-resistant tuberculosis.
Chemical nameCapreomycin sulfate
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Lin Y et al. The antituberculosis antibiotic capreomycin inhibits protein synthesis by disrupting interaction between ribosomal proteins L12 and L10. Antimicrob Agents Chemother 58:2038-44 (2014). Read more (PubMed: 24449778) »
- Akbergenov R et al. Molecular basis for the selectivity of antituberculosis compounds capreomycin and viomycin. Antimicrob Agents Chemother 55:4712-7 (2011). Read more (PubMed: 21768509) »
- Stanley RE et al. The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome. Nat Struct Mol Biol 17:289-93 (2010). Read more (PubMed: 20154709) »
- Maus CE et al. Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother 49:571-7 (2005). Read more (PubMed: 15673735) »