Capreomycin sulfate, peptide antibiotic (ab145807)

Overview

  • Product name

    Capreomycin sulfate, peptide antibiotic
  • Description

    Cyclic peptide antibiotic belonging to the tuberactinomycin family of antibiotics.
  • Alternative names

    • Capreomycin sulfate salt
  • Biological description

    Cyclic peptide antibiotic thought to inhibit protein synthesis by binding to the 70S ribosomal unit. Disrupts interaction of Mycobacterium tuberculosis ribosomal proteins L12 and L10. Tuberactinomycin antibiotic given in combination with other antibiotics for multidrug-resistant tuberculosis.

  • CAS Number

    1405-37-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Capreomycin sulfate
  • Molecular weight

    750.78
  • Molecular formula

    C25H44N14O7.H2SO4
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Lin Y  et al. The antituberculosis antibiotic capreomycin inhibits protein synthesis by disrupting interaction between ribosomal proteins L12 and L10. Antimicrob Agents Chemother 58:2038-44 (2014). Read more (PubMed: 24449778) »
  • Akbergenov R  et al. Molecular basis for the selectivity of antituberculosis compounds capreomycin and viomycin. Antimicrob Agents Chemother 55:4712-7 (2011). Read more (PubMed: 21768509) »
  • Stanley RE  et al. The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome. Nat Struct Mol Biol 17:289-93 (2010). Read more (PubMed: 20154709) »
  • Maus CE  et al. Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother 49:571-7 (2005). Read more (PubMed: 15673735) »

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