Overview

  • Product name

    Capsazepine, VR1 antagonist
  • Description

    VR1 antagonist
  • Biological description

    VR1 vanilloid receptor antagonist (IC50 = 562 nM). Analgesic in vivo.
  • Purity

    > 99%
  • CAS Number

    138977-28-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Menéndez L  et al. Analgesic effects of capsazepine and resiniferatoxin on bone cancer pain in mice. Neurosci Lett 393:70-3 (2006). Read more (PubMed: 16243435) »
  • Seabrook GR  et al. Functional properties of the high-affinity TRPV1 (VR1) vanilloid receptor antagonist (4-hydroxy-5-iodo-3-methoxyphenylacetate ester) iodo-resiniferatoxin. J Pharmacol Exp Ther 303:1052-60 (2002). Read more (PubMed: 12438527) »
  • Walpole CS  et al. The discovery of capsazepine, the first competitive antagonist of the sensory neuron excitants capsaicin and resiniferatoxin. J Med Chem 37:1942-54 (1994). Read more (PubMed: 8027976) »
  • Perkins MN & Campbell EA Capsazepine reversal of the antinociceptive action of capsaicin in vivo. Br J Pharmacol 107:329-33 (1992). Read more (PubMed: 1422585) »
See all 7 Publications for this product

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