Overview

  • Product name

    Captopril, ACE inhibitor
  • Description

    Potent ACE inhibitor
  • Biological description

    Potent ACE inhibitor (IC50 = 21 nM). Reversible and competitive leukotriene A4 hydrolase inhibitor (Ki = 6 μM, leukotriene B4 formation). Vasodilatory and antihypertensive effects in vivo. Orally active.
  • Purity

    > 98%
  • General notes

    In aqueous solution, this product undergoes a free radical dimerisation to form captopril disulfide. This dimerisation is oxygen-facilitated and has been found to be pH dependent and catalysed by metal ions. To delay oxidation use a lower pH (maximum stability at pH <4), incorporate a chelating agent or antioxidant, degas solutions, minimise headspace or increase product concentration.

  • CAS Number

    62571-86-2
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Davis TA  et al. Timing of captopril administration determines radiation protection or radiation sensitization in a murine model of total body irradiation. Exp Hematol 38:270-81 (2010). Read more (PubMed: 20116413) »
  • Orning L  et al. Inhibition of leukotriene A4 hydrolase/aminopeptidase by captopril. J Biol Chem 266:16507-11 (1991). Read more (PubMed: 1885582) »
  • [Effect of angiotensin-converting enzyme inhibitors, beta-adrenoblockers, and their combinations on survival and plasma catecholamine levels in rats with chronic heart failure with induced exacerbations]. Zh Evol Biokhim Fiziol 49:224-32 (0). Read more (PubMed: 24450223) »

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