Overview

  • Product name

    Carbamazepine, Neuronal voltage-gated Na+ channel blocker
  • Description

    Neuronal voltage-gated Na+ channel blocker
  • Biological description

    Neuronal voltage-gated Na+ channel blocker. Shows anticonvulsant effects in vivo. Attenuates neuropathic pain behaviours. Potent GABAA current potentiator (EC50 = 25 nM). Orally and centrally active.
  • Purity

    > 98%
  • CAS Number

    289-46-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Benzo[b][1]benzazepine-11-carboxamide
  • Molecular weight

    236.30
  • Molecular formula

    C15H12N2O
  • PubChem identifier

    2554
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C2C(=C1)C=CC3=CC=CC=C3N2C(=O)N
  • Source

    Synthetic

  • Research areas

Images

  • Carbamazepine inhibits Nav1.2 channels currents in Xenopusoocytes.

    A. Time course of NaV1.2 channel reversible inhibition by 100 µM and 1 mM Carbamazepine (ab141785). Currents were elicited by a voltage step to -20 mV (100 ms) every 10 seconds from a holding potential of -100 mV. 

    B. Example traces of current response to voltage step application before and during 1 mM Carbamazepine application.

References

This product has been referenced in:

  • Hahm TS  et al. Combined carbamazepine and pregabalin therapy in a rat model of neuropathic pain. Br J Anaesth 109:968-74 (2012). Read more (PubMed: 22936823) »
  • Lipkind GM & Fozzard HA Molecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore. Mol Pharmacol 78:631-8 (2010). Read more (PubMed: 20643904) »
  • Granger P  et al. Modulation of the gamma-aminobutyric acid type A receptor by the antiepileptic drugs carbamazepine and phenytoin. Mol Pharmacol 47:1189-96 (1995). Read more (PubMed: 7603459) »
See 1 Publication for this product

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