Anti-Carbamyl-lysine antibody (ab175132)

Carbamylation is a post-translational modification which occurs throughout the lifespan of proteins in vivo. Carbamylation results from the binding of isocyanic acid, spontaneously derived from high concentrations of urea and leading to the formation of carbamyl-lysine (CBL). The carbamylation of proteins is usually associated with a partial or complete loss of protein function. It is known that elevated urea directly induces the formation of potentially atherogenic carbamylated LDL (cLDL). High blood concentrations of urea leading to the carbamylation process were detected in uremic patients and patients with end-stage renal disease.