Key features and details
- Rabbit polyclonal to Carbonic Anhydrase 12/CA12
- Suitable for: IHC-P, WB
- Reacts with: Mouse, Human
- Isotype: IgG
Product nameAnti-Carbonic Anhydrase 12/CA12 antibody
See all Carbonic Anhydrase 12/CA12 primary antibodies
DescriptionRabbit polyclonal to Carbonic Anhydrase 12/CA12
Tested applicationsSuitable for: IHC-P, WBmore details
Species reactivityReacts with: Mouse, Human
Recombinant fragment corresponding to Human Carbonic Anhydrase 12/CA12 aa 25-301.
APVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPL EFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGN PNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLI EMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGS LTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNF RQVQKFDERLVYTSFSQVQVCTAAGLS
Database link: O43570
- Human kidney and colon tissues; Mouse kidney tissue lysate.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.40
Preservative: 0.03% Proclin 300
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityCaprylic Acid - Ammonium Sulfate precipitation
Our Abpromise guarantee covers the use of ab218983 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 7.5 µg/ml.|
|WB||Use a concentration of 6 µg/ml. Predicted molecular weight: 39 kDa.|
FunctionReversible hydration of carbon dioxide.
Tissue specificityHighly expressed in colon, kidney, prostate, intestine and activated lymphocytes. Expressed at much higher levels in the renal cell cancers than in surrounding normal kidney tissue. Moderately expressed in pancreas, ovary and testis.
Involvement in diseaseDefects in CA12 are the cause of hyperchlorhidrosis isolated (HCHLH) [MIM:143860]. HCHLH is a disorder characterized by excessive sweating and increased sweat chloride levels. Affected individuals suffer from episodes of hyponatremic dehydration and report increased amounts of visible salt precipitates in sweat.
Sequence similaritiesBelongs to the alpha-carbonic anhydrase family.
- Information by UniProt
- CA 12 antibody
- CA XII antibody
- CA-XII antibody
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human kidney tissue labeling CA12 with ab218983 at 7.5 μg/ml.
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human colon tissue labeling CA12 with ab218983 at 7.5 μg/ml.
Anti-Carbonic Anhydrase 12/CA12 antibody (ab218983) at 6 µg/ml + Mouse kidney tissue lysate
Goat polyclonal to Rabbit IgG at 1/1000 dilution
Predicted band size: 39 kDa
ab218983 has not yet been referenced specifically in any publications.