Anti-Carbonic Anhydrase 9/CA9 antibody [PN-15] (ab233986)

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Overview

  • Product name

    Anti-Carbonic Anhydrase 9/CA9 antibody [PN-15]
    See all Carbonic Anhydrase 9/CA9 primary antibodies

  • Description

    Mouse monoclonal [PN-15] to Carbonic Anhydrase 9/CA9

  • Host species

    Mouse

  • Tested applications

    Suitable for: IHC-Pmore details

  • Species reactivity

    Reacts with: Horse, Human

  • Immunogen

    Tissue, cells or virus corresponding to Human Carbonic Anhydrase 9/CA9. Microsomal fraction of human renal cortical tissue homogenate.

  • Positive control

    • IHC-P: Human renal cell carcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab233986 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 0.5 - 1 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Incubate with primary antibody for 30 minutes at room temperature.

Target

  • Function

    Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia.

  • Tissue specificity

    Expressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa.

  • Sequence similarities

    Belongs to the alpha-carbonic anhydrase family.
    Contains 1 alpha-carbonic anhydrase domain.

  • Post-translational
    modifications

    Asn-346 bears high-mannose type glycan structures.

  • Cellular localization

    Nucleus. Nucleus, nucleolus. Cell membrane. Cell projection, microvillus membrane. Found on the surface microvilli and in the nucleus, particularly in nucleolus.
  • Information by UniProt

  • Database links

    • Alternative names

      • CA-IX antibody
      • CA9 antibody
      • CAH9_HUMAN antibody
      • CAIX antibody
      • Carbonate dehydratase IX antibody
      • Carbonic anhydrase 9 antibody
      • Carbonic anhydrase IX antibody
      • Carbonic dehydratase antibody
      • G250 antibody
      • Membrane antigen MN antibody
      • MN antibody
      • P54/58N antibody
      • pMW1 antibody
      • RCC associated protein G250 antibody
      • RCC-associated antigen G250 antibody
      • Renal cell carcinoma-associated antigen G250 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Carbonic Anhydrase 9/CA9 antibody [PN-15] (ab233986)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Carbonic Anhydrase 9/CA9 antibody [PN-15] (ab233986)

      Formalin-fixed, paraffin-embedded human renal cell carcinoma tissue stained for Carbonic Anhydrase 9/CA9 using ab233986 at 1 μg/ml in immunohistochemical analysis.

    References

    ab233986 has not yet been referenced specifically in any publications.

    Publishing research using ab233986? Please let us know so that we can cite the reference in this datasheet.

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