HRP Anti-Carbonic anhydrase 2/CA2 antibody (ab34586)
Key features and details
- HRP Rabbit polyclonal to Carbonic anhydrase 2/CA2
- Suitable for: ELISA, Dot blot
- Reacts with: Cow
- Conjugation: HRP
- Isotype: IgG
Overview
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Product name
HRP Anti-Carbonic anhydrase 2/CA2 antibody
See all Carbonic anhydrase 2/CA2 primary antibodies -
Description
HRP Rabbit polyclonal to Carbonic anhydrase 2/CA2 -
Host species
Rabbit -
Conjugation
HRP -
Tested applications
Suitable for: ELISA, Dot blotmore details -
Species reactivity
Reacts with: Cow -
Immunogen
Full length native protein (purified) corresponding to Cow Carbonic anhydrase 2/CA2.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
pH: 6.50
Preservative: 0.01% Gentamicin sulphate
Constituents: 1% BSA, 0.42% Tripotassium orthophosphate, 0.87% Sodium chloride -
Concentration information loading...
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Purity
IgG fraction -
Purification notes
Purified by delipidation, salt fractionation and ion exchange chromatography. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Recombinant Protein
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Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab34586 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
ELISA |
1/5000 - 1/20000.
|
|
Dot blot |
Use at an assay dependent concentration.
|
Notes |
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ELISA
1/5000 - 1/20000. |
Dot blot
Use at an assay dependent concentration. |
Target
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Function
Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. -
Involvement in disease
Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation. -
Sequence similarities
Belongs to the alpha-carbonic anhydrase family. -
Cellular localization
Cytoplasm. - Information by UniProt
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Database links
- Entrez Gene: 280740 Cow
- SwissProt: P00921 Cow
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Alternative names
- CA 2 antibody
- CA II antibody
- CA-II antibody
see all
Datasheets and documents
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Datasheet download
References (0)
ab34586 has not yet been referenced specifically in any publications.