Key features and details
- Mouse monoclonal [CMS-10] to Carboxymethyl Lysine
- Suitable for: ELISA, IHC-Fr, IHC-P
- Reacts with: Species independent
- Isotype: IgG1
Product nameAnti-Carboxymethyl Lysine antibody [CMS-10]
See all Carboxymethyl Lysine primary antibodies
DescriptionMouse monoclonal [CMS-10] to Carboxymethyl Lysine
Tested applicationsSuitable for: ELISA, IHC-Fr, IHC-Pmore details
Species reactivityReacts with: Species independent
N epsilon (Carboxymethyl) Lysine (CML) conjugated to KLH.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.1% CMIT/MIT 3:1
Ascites in stabilized buffer, containing 50% Block Ace (Casein-containing solution) and 0.1% ProClin as a preservative.
Concentration information loading...
PurityProtein G purified
- Pathways and Processes
- Metabolic signaling pathways
- Energy transfer pathways
- Energy Metabolism
Our Abpromise guarantee covers the use of ab30922 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ELISA||Use a concentration of 0.1 - 0.5 µg/ml.|
|IHC-Fr||Use a concentration of 2 µg/ml.|
|IHC-P||Use at an assay dependent concentration.|
RelevanceN epsilon carboxymethyl lysine (CML or Carboxymethyl Lysine) is formed by the non enzymatic Schiff base reaction of glucose with proteins, followed by an Amadori rearrangement and oxidation that leaves only a carboxymethyl group attached to the lysine. The levels of CML adducts accumulate over time and have been used as an indicator of both serum glucose levels and oxidative protein damage. Elevated serum CML modified proteins have been associated with diabetes and may contribute to diabetic retinopathy, nephropathy and angiopathy.
- CML antibody
- N Epsilon (Carboxymethyl) Lysine antibody
ab30922 has been referenced in 2 publications.
- Portal-Núñez S et al. Adverse Effects of Diabetes Mellitus on the Skeleton of Aging Mice. J Gerontol A Biol Sci Med Sci 71:290-9 (2016). PubMed: 26386012
- de la Maza MP et al. Weight increase is associated with skeletal muscle immunostaining for advanced glycation end products, receptor for advanced glycation end products, and oxidation injury. Rejuvenation Res 11:1041-8 (2008). IHC-P . PubMed: 19086911