Recombinant
RabMAb

Recombinant Anti-Carboxypeptidase B2 antibody [EPR7858] (ab133679)

Overview

  • Product name

    Anti-Carboxypeptidase B2 antibody [EPR7858]
    See all Carboxypeptidase B2 primary antibodies
  • Description

    Rabbit monoclonal [EPR7858] to Carboxypeptidase B2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: IHC-P or IP
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to a region within Human Carboxypeptidase B2 (UniProt ID: Q96IY4).

  • Positive control

    • Human platelet and plasma lysates
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab133679 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 48 kDa.
  • Application notes
    Is unsuitable for IHC-P or IP.
  • Target

    • Relevance

      This protein belongs to a family of Zn-containing metallocarboxypeptidases specific to C-terminal lysine and arginine residues. It circulates in plasma as a zymogen with molecular weight of 55 kDa (401 amino acid residues; pI 5.0). Being activated by thrombin-thrombomodulin complex during blood coagulation, it exerts carboxypeptidase activity. Activated carboxypeptidase B2 removes C-terminal lysine residues from fibrin, which is necessary for plasminogen binding to fibrin. This prevents plasminogen from activation into plasmin and retards the lysis of a fibrin clot. The concentration in plasma of healthy people is 5 – 10 µg/ml. High plasma levels were found in patients with stable angina pectoris and angiographically verified coronary artery disease. Elevated concentration in blood is considered as a risk factor for venous thrombosis. A deficiency might contribute to the severity of bleeding disorders in hemophilias A and B, and decreased levels are found in chronic liver disease.
    • Cellular localization

      Secreted
    • Database links

    • Alternative names

      • 1110032P04Rik antibody
      • 4930405E17Rik antibody
      • bA139H14.2 antibody
      • Carboxypeptidase B like protein antibody
      • Carboxypeptidase U antibody
      • CarboxypeptidaseB2 antibody
      • CarboxypeptidaseU antibody
      • CP B2 antibody
      • CPB 2 antibody
      • CPB2 antibody
      • CPU antibody
      • PCPB antibody
      • Plasma carboxypeptidase B antibody
      • Plasma carboxypeptidase B2 antibody
      • Procarboxypeptidase B antibody
      • Procarboxypeptidase R antibody
      • Procarboxypeptidase U antibody
      • TAFI antibody
      • Thrombin activable fibrinolysis inhibitor antibody
      • Thrombin activatable fibrinolysis inhibitor antibody
      see all

    Images

    • All lanes : Anti-Carboxypeptidase B2 antibody [EPR7858] (ab133679) at 1/1000 dilution

      Lane 1 : Human platelet lysate
      Lane 2 : Human plasma lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution

      Predicted band size: 48 kDa

    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    References

    ab133679 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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