Overview

  • Product name

  • Description

    Rabbit polyclonal to CARD14
  • Host species

    Rabbit
  • Specificity

    At least three isoforms of CARD14 (CARMA2) are known to exist; this antibody will only detect isoform 1. ab140203 is predicted not to cross-react with other CARMA proteins.
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    A 14 amino acid synthetic peptide derived from near the C terminal of Human CARD14.

  • Positive control

    • Human placenta tissue

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer

    Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab140203 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml.

Target

  • Function

    Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
  • Tissue specificity

    Expressed in placenta. Also detected in HeLaS3 cell line, but not in the other cancer cell lines tested. Expressed in epidermal keratinocytes.
  • Involvement in disease

    Defects in CARD14 are the cause of susceptibility to psoriasis type 2 (PSORS2) [MIM:602723]. A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
    Defects in CARD14 are the cause of pityriasis rubra pilaris (PRP) [MIM:173200]. A rare, papulosquamous skin disease characterized by the appearance of keratotic follicular papules, well-demarcated salmon-colored erythematous plaques covered with fine powdery scales interspersed with distinct islands of uninvolved skin, and palmoplantar keratoderma. Most cases are sporadic. The rare familial cases show autosomal dominant inheritance with incomplete penetrance and variable expression. Familial PRP usually presents at birth or appears during the first years of life and runs a chronic course. It is characterized by prominent follicular hyperkeratosis, diffuse palmoplantar keratoderma, and erythema.
  • Sequence similarities

    Contains 1 CARD domain.
    Contains 1 guanylate kinase-like domain.
    Contains 1 PDZ (DHR) domain.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • Bcl10 interacting MAGUK protein 2 antibody
    • Bimp 2 antibody
    • Bimp2 antibody
    • CAR14_HUMAN antibody
    • CARD 14 antibody
    • CARD containing MAGUK 2 protein antibody
    • CARD containing MAGUK protein 2 antibody
    • Card maguk protein 2 antibody
    • CARD-containing MAGUK protein 2 antibody
    • CARD14 antibody
    • Carma 2 antibody
    • Carma2 antibody
    • Caspase recruitment domain containing protein 14 antibody
    • Caspase recruitment domain family member 14 antibody
    • Caspase recruitment domain protein 14 antibody
    • Caspase recruitment domain-containing protein 14 antibody
    • PRP antibody
    • PSORS2 antibody
    • PSS1 antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human placenta tissue labelling CARD14 with ab140203 at 5 µg/ml.

References

ab140203 has not yet been referenced specifically in any publications.

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