Overview

  • Product name

  • Description

    Rabbit polyclonal to CARD9
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-P, ICCmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Dog
  • Immunogen

    Synthetic peptide:

    DRENTTGSDNTDTEGS

    conjugated to KLH, corresponding to amino acids 521-536 of Human CARD9 (NP_434700.2).

  • Positive control

    • Human adrenal tissue.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at -80°C.
  • Storage buffer

    Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Protein A purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab115578 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 62 kDa.
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC Use at an assay dependent concentration.

Target

  • Function

    Activates NF-kappa-B via BCL10.
  • Tissue specificity

    Highly expressed in spleen. Also detected in liver, placenta, lung, peripheral blood leukocytes and in brain.
  • Involvement in disease

    Defects in CARD9 are the cause of familial candidiasis type 2 (CANDF2) [MIM:212050]. Chronic mucocutaneous candidiasis is characterized by impaired clearance of fungal infections and results in colonization and infections of the mucosa or skin, predominantly with Candida albicans. CANDF2 is an autosomal recessive chronic mucocutaneous candidiasis.
  • Sequence similarities

    Contains 1 CARD domain.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • CANDF2 antibody
    • CARD9 antibody
    • CARD9_HUMAN antibody
    • Caspase recruitment domain family member 9 antibody
    • Caspase recruitment domain-containing protein 9 antibody
    • hCARD9 antibody
    see all

Images

  • ab115578, at 10µg/ml, staining CARD9 in Formalin-fixed, Paraffin-embedded Human Adrenal tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References

ab115578 has not yet been referenced specifically in any publications.

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