Product nameAnti-Cardiac Troponin C antibody [7B9] (HRP)
See all Cardiac Troponin C primary antibodies
DescriptionMouse monoclonal [7B9] to Cardiac Troponin C (HRP)
Tested applicationsSuitable for: Sandwich ELISA, WB, ELISAmore details
Species reactivityReacts with: Human
Full length protein (Human).
Reconizes TnC in binary complex with cTnI, has no cross reaction with cTnT and cTnI.
Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferPreservative: 0.05% Proclin
Constituents: PBS, pH 7.4
Concentration information loading...
PurityProtein A purified
Primary antibody notesReconizes TnC in binary complex with cTnI, has no cross reaction with cTnT and cTnI.
Light chain typeunknown
- TMB ELISA Substrate (Highest Sensitivity) (ab171522)
- TMB ELISA Substrate (High Sensitivity) (ab171523)
- TMB ELISA Substrate (Fast Kinetic Rate) (ab171524)
- TMB ELISA Substrate (Slow Kinetic Rate) (ab171525)
- TMB ELISA Substrate (Slower Kinetic Rate) (ab171526)
- TMB ELISA Substrate (Slowest Kinetic Rate) (ab171527)
- 450 nm Stop Solution for TMB Substrate (ab171529)
- 650 nm Stop Solution for TMB Substrate (ab171531)
- Immunoassay Blocking Buffer (ab171534)
- Immunoassay Blocking (BSA Free) (ab171535)
- Recombinant Rabbit Troponin C protein (ab9917)
Our Abpromise guarantee covers the use of ab8286 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Sandwich ELISA||Use at an assay dependent dilution. Can be used as Detection antibody.|
|WB||Use at an assay dependent dilution.|
|ELISA||Use at an assay dependent dilution.|
|AP||Use at an assay dependent dilution.|
FunctionTroponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Involvement in diseaseDefects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z) [MIM:611879]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Defects in TNNC1 are the cause of familial hypertrophic cardiomyopathy type 13 (CMH13) [MIM:613243]. A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Sequence similaritiesBelongs to the troponin C family.
Contains 4 EF-hand domains.
- Information by UniProt
- tnnc1a antibody
- Cardiac troponin C antibody
- slow skeletal and cardiac muscles antibody
ab8286 has not yet been referenced specifically in any publications.