Product nameAnti-Cardiac Troponin C antibody [MAC 352]
See all Cardiac Troponin C primary antibodies
DescriptionRat monoclonal [MAC 352] to Cardiac Troponin C
SpecificityAntibody reacts with Troponin C isoforms F1 and F2 in flight muscle of Lethocerus and Drosophila, and with Troponin C in non-flight muscles.
Tested applicationsSuitable for: ICC/IF, Electron Microscopy, WBmore details
Species reactivityReacts with: Drosophila melanogaster, Waterbug
Troponin C purified from Lethocerus indicus (Waterbug) flight muscle.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferPreservative: 0.1% Sodium azide
Concentration information loading...
PurityProtein G purified
Clone numberMAC 352
Our Abpromise guarantee covers the use of ab51106 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ICC/IF: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Predicted molecular weight: 17 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionTroponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Involvement in diseaseDefects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z) [MIM:611879]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Defects in TNNC1 are the cause of familial hypertrophic cardiomyopathy type 13 (CMH13) [MIM:613243]. A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Sequence similaritiesBelongs to the troponin C family.
Contains 4 EF-hand domains.
- Information by UniProt
- tnnc1a antibody
- Cardiac troponin C antibody
- slow skeletal and cardiac muscles antibody
This product has been referenced in:
- Wang S et al. Mechanotransduction via the LINC complex regulates DNA replication in myonuclei. J Cell Biol 217:2005-2018 (2018). Read more (PubMed: 29650775) »
- Chechenova MB et al. The Drosophila Z-disc protein Z(210) is an adult muscle isoform of Zasp52, which is required for normal myofibril organization in indirect flight muscles. J Biol Chem 288:3718-26 (2013). IHC-Fr, WB ; Drosophila melanogaster . Read more (PubMed: 23271733) »