• Product name

    Anti-Cardiac Troponin C antibody [MAC 352]
    See all Cardiac Troponin C primary antibodies
  • Description

    Rat monoclonal [MAC 352] to Cardiac Troponin C
  • Host species

  • Specificity

    Antibody reacts with Troponin C isoforms F1 and F2 in flight muscle of Lethocerus and Drosophila, and with Troponin C in non-flight muscles.
  • Tested applications

    Suitable for: ICC/IF, Electron Microscopy, WBmore details
  • Species reactivity

    Reacts with: Drosophila melanogaster, Waterbug
  • Immunogen

    Troponin C purified from Lethocerus indicus (Waterbug) flight muscle.



Our Abpromise guarantee covers the use of ab51106 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Electron Microscopy
  • Application notes
    Electron Microscopy: Use at an assay dependent dilution.
    ICC/IF: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 17 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
    • Involvement in disease

      Defects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z) [MIM:611879]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
      Defects in TNNC1 are the cause of familial hypertrophic cardiomyopathy type 13 (CMH13) [MIM:613243]. A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
    • Sequence similarities

      Belongs to the troponin C family.
      Contains 4 EF-hand domains.
    • Information by UniProt
    • Alternative names

      • tnnc1a antibody
      • Cardiac troponin C antibody
      • slow skeletal and cardiac muscles antibody
      • TN-C antibody
      • TNC antibody
      • Tnnc1 antibody
      • TNNC1_HUMAN antibody
      • TNNI3 antibody
      • Troponin C antibody
      • Troponin C slow antibody
      • Troponin C1 slow antibody
      see all


    This product has been referenced in:

    • Wang S  et al. Mechanotransduction via the LINC complex regulates DNA replication in myonuclei. J Cell Biol 217:2005-2018 (2018). Read more (PubMed: 29650775) »
    • Chechenova MB  et al. The Drosophila Z-disc protein Z(210) is an adult muscle isoform of Zasp52, which is required for normal myofibril organization in indirect flight muscles. J Biol Chem 288:3718-26 (2013). IHC-Fr, WB ; Drosophila melanogaster . Read more (PubMed: 23271733) »
    See all 5 Publications for this product

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