Overview

  • Product name
    Anti-Cardiac Troponin I antibody
    See all Cardiac Troponin I primary antibodies
  • Description
    Rabbit polyclonal to Cardiac Troponin I
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Mouse, Pig
    Predicted to work with: Rat, Rabbit, Horse, Cow, Cat, Dog, Human
  • Immunogen

    Recombinant full length protein (His-T7-tag) corresponding to Pig Cardiac Troponin I aa 2-211. Expressed in E.coli.
    Sequence:

    ADRSGDAAGDSRPAPAPVRRRSSANYRAYATEPHAKKKSKIPASRKLQLK TLMLQIAKQELEREAEERRGEKGSALSTRCQPLELAGLSFAELQDLCRQL HARVDKVDEERYDVEAKVTKNITEIADLNQKIFDLRGKFKRPTLRRVRIS ADAMMQALLGARAKETLDLRAHLKQVKKEDTEKENREVGDWRKNIDALSG MEGRKKKFEG


    Database link: A5X497

  • Positive control
    • WB: Recombinant pig Cardiac Troponin I; mouse skeletal muscle and heart tissue lysates; pig skeletal muscle and heart lysates. IHC-P : Pig tongue and heart tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab231064 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 - 20 µg/ml.
WB Use a concentration of 0.2 - 2 µg/ml.

Target

  • Function
    Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
  • Involvement in disease
    Defects in TNNI3 are the cause of cardiomyopathy familial hypertrophic type 7 (CMH7) [MIM:613690]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
    Defects in TNNI3 are the cause of cardiomyopathy familial restrictive type 1 (RCM1) [MIM:115210]. RCM1 is an heart muscle disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function.
    Defects in TNNI3 are the cause of cardiomyopathy dilated type 2A (CMD2A) [MIM:611880]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    Defects in TNNI3 are the cause of cardiomyopathy dilated type 1FF (CMD1FF) [MIM:613286]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
  • Sequence similarities
    Belongs to the troponin I family.
  • Information by UniProt
  • Database links
  • Alternative names
    • cardiac muscle antibody
    • Cardiac troponin I antibody
    • cardiomyopathy, dilated 2A (autosomal recessive) antibody
    • Cardiomyopathy, familial hypertrophic, 7, included antibody
    • CMD1FF antibody
    • CMD2A antibody
    • CMH7 antibody
    • cTnI antibody
    • Familial hypertrophic cardiomyopathy 7 antibody
    • MGC116817 antibody
    • RCM1 antibody
    • Tn1 antibody
    • Tni antibody
    • TNN I3 antibody
    • TNNC 1 antibody
    • TNNC1 antibody
    • TNNI3 antibody
    • TNNI3_HUMAN antibody
    • Troponin I antibody
    • Troponin I cardiac antibody
    • Troponin I cardiac muscle antibody
    • Troponin I cardiac muscle isoform antibody
    • Troponin I type 3 cardiac antibody
    • troponin I, cardiac 3 antibody
    • TroponinI antibody
    • Ttroponin I type 3 (cardiac) antibody
    see all

Images

  • Formalin-fixed, paraffin-embedded pig heart tissue stained for Cardiac Troponin I with ab231064 at 20 μg/ml in immunohistochemical analysis. DAB staining.

  • Anti-Cardiac Troponin I antibody (ab231064) at 2 µg/ml + Mouse skeletal muscle lysate
  • Anti-Cardiac Troponin I antibody (ab231064) at 2 µg/ml + Pig skeletal muscle lysate
  • Anti-Cardiac Troponin I antibody (ab231064) at 2 mg/ml + Pig heart lysate
  • Anti-Cardiac Troponin I antibody (ab231064) at 2 µg/ml + Mouse heart lysate
  • Anti-Cardiac Troponin I antibody (ab231064) at 2 µg/ml + Recombinant pig Cardiac Troponin I
  • Formalin-fixed, paraffin-embedded pig tongue tissue stained for Cardiac Troponin I with ab231064 at 20 μg/ml in immunohistochemical analysis. DAB staining.

References

ab231064 has not yet been referenced specifically in any publications.

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