Key features and details
- Rabbit polyclonal to Cardiac Troponin I
- Suitable for: WB
- Reacts with: Mouse, Pig
- Isotype: IgG
Product nameAnti-Cardiac Troponin I antibody
See all Cardiac Troponin I primary antibodies
DescriptionRabbit polyclonal to Cardiac Troponin I
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse, Pig
Predicted to work with: Rat, Rabbit, Horse, Cow, Cat, Dog, Human
Recombinant fragment (His-tag) corresponding to Human Cardiac Troponin I aa 1-203. (Expressed in E.coli).
MADGSSDAAREPRPAPAPIRRRSSNYRAYATEPHAKKKSKISASRKLQLK TLLLQIAKQELEREAEERRGEKGRALSTRCQPLELAGLGFAELQDLCRQL HARVDKVDEERYDIEAKVTKNITEIADLTQKIFDLRGKFKRPTLRRVRIS ADAMMQALLGARAKESLDLRAHLKQVKKEDTEKENREVGDWRKNIDALSG MEG
Database link: P19429
- WB: Mouse heart and skeletal muscle lysates; Pig heart and skeletal muscle lysates; Recombinant human Cardiac Troponin I protein.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Purification notesab231679 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Our Abpromise guarantee covers the use of ab231679 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 24 kDa.|
FunctionTroponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Involvement in diseaseDefects in TNNI3 are the cause of cardiomyopathy familial hypertrophic type 7 (CMH7) [MIM:613690]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Defects in TNNI3 are the cause of cardiomyopathy familial restrictive type 1 (RCM1) [MIM:115210]. RCM1 is an heart muscle disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function.
Defects in TNNI3 are the cause of cardiomyopathy dilated type 2A (CMD2A) [MIM:611880]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Defects in TNNI3 are the cause of cardiomyopathy dilated type 1FF (CMD1FF) [MIM:613286]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Sequence similaritiesBelongs to the troponin I family.
- Information by UniProt
- cardiac muscle antibody
- Cardiac troponin I antibody
- cardiomyopathy, dilated 2A (autosomal recessive) antibody
All lanes : Anti-Cardiac Troponin I antibody (ab231679) at 2 µg/ml
Lane 1 : Mouse heart lysate
Lane 2 : Mouse skeletal muscle lysate
Lane 3 : Pig heart lysate
Lane 4 : Pig skeletal muscle lysate
Predicted band size: 24 kDa
Anti-Cardiac Troponin I antibody (ab231679) at 2 µg/ml + Recombinant human Cardiac Troponin I protein
Predicted band size: 24 kDa
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab231679 has not yet been referenced specifically in any publications.