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Signal Transduction Cytoskeleton / ECM Cytoskeleton Microfilaments Actin etc Troponin
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Anti-Cardiac Troponin I (phospho S150) antibody (ab169867)

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Western blot - Anti-Cardiac Troponin I (phospho S150) antibody (ab169867)

    Key features and details

    • Rabbit polyclonal to Cardiac Troponin I (phospho S150)
    • Suitable for: WB
    • Reacts with: Mouse
    • Isotype: IgG

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    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    Protein
    Recombinant Human Cardiac Troponin I protein (ab207624)

    View more associated products

    Overview

    • Product name

      Anti-Cardiac Troponin I (phospho S150) antibody
      See all Cardiac Troponin I primary antibodies
    • Description

      Rabbit polyclonal to Cardiac Troponin I (phospho S150)
    • Host species

      Rabbit
    • Tested Applications & Species

      Application Species
      WB
      Mouse
      See all applications and species data
    • Immunogen

      Synthetic peptide corresponding to Mouse Cardiac Troponin I (phospho S150).
      Database link: P19429

    • Positive control

      • Mouse heart lysate

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.
    • Storage buffer

      pH: 7.50
      Constituents: 0.24% HEPES, 0.88% Sodium chloride, 0.01% BSA, 50% Glycerol
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Signal Transduction
      • Cytoskeleton / ECM
      • Cytoskeleton
      • Microfilaments
      • Actin etc
      • Troponin
      • Stem Cells
      • Lineage Markers
      • Mesoderm
      • Cardiovascular
      • Heart
      • Contractility
      • Contractile Proteins
      • Troponin
      • Developmental Biology
      • Lineage specification
      • Mesoderm
      • Cardiovascular
      • Cardiovascular Markers
      • Cell Markers
      • Cardiomyocytes

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
    • Positive Controls

      • Mouse heart normal tissue lysate - total protein (ab30291)
    • Recombinant Protein

      • Recombinant Human Cardiac Troponin I protein (ab207624)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab169867 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Guaranteed

    Tested applications are guaranteed to work and covered by our Abpromise guarantee.

    Predicted

    Predicted to work for this combination of applications and species but not guaranteed.

    Incompatible

    Does not work for this combination of applications and species.

    Application Species
    WB
    Mouse
    All applications
    Human
    Non human primates
    Application Abreviews Notes
    WB
    1/1000. Predicted molecular weight: 24 kDa.
    Notes
    WB
    1/1000. Predicted molecular weight: 24 kDa.

    Target

    • Function

      Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
    • Involvement in disease

      Defects in TNNI3 are the cause of cardiomyopathy familial hypertrophic type 7 (CMH7) [MIM:613690]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
      Defects in TNNI3 are the cause of cardiomyopathy familial restrictive type 1 (RCM1) [MIM:115210]. RCM1 is an heart muscle disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function.
      Defects in TNNI3 are the cause of cardiomyopathy dilated type 2A (CMD2A) [MIM:611880]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
      Defects in TNNI3 are the cause of cardiomyopathy dilated type 1FF (CMD1FF) [MIM:613286]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    • Sequence similarities

      Belongs to the troponin I family.
    • Target information above from: UniProt accession P19429 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 7137 Human
      • Entrez Gene: 21954 Mouse
      • Omim: 191044 Human
      • SwissProt: P19429 Human
      • SwissProt: P48787 Mouse
      • Unigene: 709179 Human
      • Unigene: 27674 Mouse
      • Alternative names

        • cardiac muscle antibody
        • Cardiac troponin I antibody
        • cardiomyopathy, dilated 2A (autosomal recessive) antibody
        • Cardiomyopathy, familial hypertrophic, 7, included antibody
        • CMD1FF antibody
        • CMD2A antibody
        • CMH7 antibody
        • cTnI antibody
        • Familial hypertrophic cardiomyopathy 7 antibody
        • MGC116817 antibody
        • RCM1 antibody
        • Tn1 antibody
        • Tni antibody
        • TNN I3 antibody
        • TNNC 1 antibody
        • TNNC1 antibody
        • TNNI3 antibody
        • TNNI3_HUMAN antibody
        • Troponin I antibody
        • Troponin I cardiac antibody
        • Troponin I cardiac muscle antibody
        • Troponin I cardiac muscle isoform antibody
        • Troponin I type 3 cardiac antibody
        • troponin I, cardiac 3 antibody
        • TroponinI antibody
        • Ttroponin I type 3 (cardiac) antibody
        see all

      Images

      • Western blot - Anti-Cardiac Troponin I (phospho S150) antibody (ab169867)
        Western blot - Anti-Cardiac Troponin I (phospho S150) antibody (ab169867)
        All lanes : Anti-Cardiac Troponin I (phospho S150) antibody (ab169867) at 1/1000 dilution

        Lane 1 : Mouse heart lysate
        Lane 2 : Mouse heart lysate incubated in lambda-Ptase (1400 units for 30 min).

        Predicted band size: 24 kDa

      Protocols

      • Western blot protocols

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
    • References (1)

      Publishing research using ab169867? Please let us know so that we can cite the reference in this datasheet.

      ab169867 has been referenced in 1 publication.

      • Birch CL  et al. Sex dimorphisms of crossbridge cycling kinetics in transgenic hypertrophic cardiomyopathy mice. Am J Physiol Heart Circ Physiol 311:H125-36 (2016). PubMed: 27199124

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