• Product name
    Anti-Cardiotrophin 1 antibody [3G6D9]
    See all Cardiotrophin 1 primary antibodies
  • Description
    Mouse monoclonal [3G6D9] to Cardiotrophin 1
  • Host species
  • Tested applications
    Suitable for: IHC-P, WB, ELISAmore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Recombinant full length protein (Human). (N-terminal HisTag, 22.5 kDa protein, 200 aa residues of the human cardiotrophin and 12 additional aa residues).

  • General notes

    Abcam is committed to meeting high standards of ethical manufacturing and as such, we will be discontinuing this product, which has been generated by the ascites method, within the next year. We are sorry for any inconvenience this may cause. If you would like help finding an alternative product, please do not hesitate to contact our scientific support team.



Our Abpromise guarantee covers the use of ab13975 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 1 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB Use at an assay dependent concentration. Predicted molecular weight: 24 kDa.
ELISA Use at an assay dependent concentration.


  • Function
    Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.
  • Tissue specificity
    Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, colon or peripheral blood leukocytes.
  • Sequence similarities
    Belongs to the IL-6 superfamily.
  • Cellular localization
  • Information by UniProt
  • Database links
  • Alternative names
    • Cardiophin 1 antibody
    • Cardiophin1 antibody
    • Cardiotrophin I antibody
    • Cardiotrophin-1 antibody
    • Cardiotrophin1 antibody
    • CardiotrophinI antibody
    • CT 1 antibody
    • CT-1 antibody
    • CT1 antibody
    • CTF 1 antibody
    • Ctf1 antibody
    • CTF1_HUMAN antibody
    see all


  • IHC image of ab13975 staining in human normal heart formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab13975, 1µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

    For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.


This product has been referenced in:
  • Nogueira-Silva C  et al. The role of glycoprotein 130 family of cytokines in fetal rat lung development. PLoS One 8:e67607 (2013). Read more (PubMed: 23826327) »
  • Natal C  et al. Cardiotrophin-1 is expressed in adipose tissue and upregulated in the metabolic syndrome. Am J Physiol Endocrinol Metab 294:E52-60 (2008). Read more (PubMed: 17940213) »

See all 2 Publications for this product

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