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Rabbit monoclonal [EPR2557] to Carma 1 / CARD11
WB more details Unsuitable for:
Flow Cyt,ICC,IHC-P or IP
Human Does not react with:
Synthetic peptide within Human Carma 1/ CARD11 aa 1100-1200 (C terminal). The exact sequence is proprietary.
Lysates of: Molt-4, Ramos, Jurkat, K562
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Dissociation constant (K
Preservative: 0.05% Sodium azide Constituents: 40% Glycerol, 9.85% Tris glycine, 50% Tissue culture supernatant
Tissue culture supernatant
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1000 - 1/10000. Predicted molecular weight: 133 kDa.
Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLa S3, Molt-4, A549 and G431 cells.
Contains 1 CARD domain.
Contains 1 guanylate kinase-like domain. Contains 1 PDZ (DHR) domain.
Phosphorylation at Ser-559, Ser-644 and Ser-652 by PRKCBB leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling.
Cytoplasm. Membrane raft. Colocalized with DPP4 in membrane rafts.
Information by UniProt
Bcl10 interacting maguk protein 3 antibody
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"