Overview

  • Product name

    Carmofur, Antimetabolite agent
  • Description

    Potent acid ceramidase inhibitor. Antimetabolite agent.
  • Biological description

    Potent acid ceramidase inhibitor (IC50 = 29 nM). Antimetabolite agent. cytostatic pyrimidine analogue derivative of fluorouracil (Asc 2387) . Shows antitumor effects in vivo. Orally active.
  • Purity

    > 97%
  • CAS Number

    61422-45-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-Fluoro-N-hexyl-2,4-dioxopyrimidine-1-carboxamide
  • Molecular weight

    257.26
  • Molecular formula

    C11H16FN3O3
  • PubChem identifier

    2577
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCCCNC(=O)N1C=C(C(=O)NC1=O)F
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Realini N  et al. Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity. Sci Rep 3:1035 (2013). Read more (PubMed: 23301156) »
  • Pizzirani D  et al. Discovery of a new class of highly potent inhibitors of acid ceramidase: synthesis and structure-activity relationship (SAR). J Med Chem 56:3518-30 (2013). Read more (PubMed: 23614460) »
  • Ooi A  et al. Plasma, intestine and tumor levels of 5-fluorouracil in mice bearing L1210 ascites tumor following oral administration of 5-fluorouracil, UFT (mixed compound of tegafur and uracil), carmofur and 5'-deoxy-5-fluorouridine. Biol Pharm Bull 24:1329-31 (2001). Read more (PubMed: 11725974) »

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