Overview

  • Product name
    Anti-Casein Kinase 1 delta / CSNK1D antibody
    See all Casein Kinase 1 delta / CSNK1D primary antibodies
  • Description
    Rabbit polyclonal to Casein Kinase 1 delta / CSNK1D
  • Host species
    Rabbit
  • Specificity
    ab37971 recognizes Casein Kinase 1 delta / CSNK1D.
  • Tested applications
    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human Casein Kinase 1 delta/ CSNK1D (C terminal) conjugated to keyhole limpet haemocyanin.

  • Positive control
    • HeLa cell lysate (WB), human breast carcinoma and human hepatocarcinoma tissue.
  • General notes

    Previously labelled as Casein Kinase 1 delta. 

Properties

Applications

Our Abpromise guarantee covers the use of ab37971 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Detects a band of approximately 47 kDa.
ELISA 1/1000.
IHC-P 1/50 - 1/100.

Target

  • Function
    Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm.
  • Tissue specificity
    Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes.
  • Involvement in disease
    Defects in CSNK1D are a cause of familial advanced sleep-phase syndrome (FASPS) [MIM:604348]. FASPS is characterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and melatonin rhythms.
  • Sequence similarities
    Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Autophosphorylated on serine and threonine residues.
  • Cellular localization
    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Casein Kinase 1 delta antibody
    • Casein kinase I delta isoform antibody
    • Casein kinase I isoform delta antibody
    • CKI delta antibody
    • CKI-delta antibody
    • CKId antibody
    • CKIdelta antibody
    • CSNK 1D antibody
    • CSNK1D antibody
    • HCKID antibody
    • KC1D_HUMAN antibody
    • Protein kinase CK1 delta antibody
    see all

Images

  • Anti-Casein Kinase 1 delta / CSNK1D antibody (ab37971) + HeLa cell lysate

    Secondary
    HRP-anti-rabbit

    Observed band size: 47 kDa
    why is the actual band size different from the predicted?

  • Formalin-fixed and paraffin-embedded human cancer tissue reacted with ab37971, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. HC = hepatocarcinoma.

References

This product has been referenced in:
  • Lund H  et al. MARK4 and MARK3 associate with early tau phosphorylation in Alzheimer's disease granulovacuolar degeneration bodies. Acta Neuropathol Commun 2:22 (2014). Read more (PubMed: 24533944) »
See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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