Anti-Casein Kinase 1 delta/CSNK1D antibody (ab10877)
Key features and details
- Goat polyclonal to Casein Kinase 1 delta/CSNK1D
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-Casein Kinase 1 delta/CSNK1D antibody
See all Casein Kinase 1 delta/CSNK1D primary antibodies -
Description
Goat polyclonal to Casein Kinase 1 delta/CSNK1D -
Host species
Goat -
Specificity
ab10877 is specific for human Casein Kinase 1 delta/CSNK1D.
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Species reactivity
Reacts with: Mouse, Human -
Immunogen
Synthetic peptide corresponding to Human Casein Kinase 1 delta/CSNK1D aa 310-327 (C terminal).
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General notes
Previously labelled as Casein Kinase 1 delta.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.09% Sodium azide -
Concentration information loading...
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Purity
Whole antiserum -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Target
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Function
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. -
Tissue specificity
Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes. -
Involvement in disease
Defects in CSNK1D are a cause of familial advanced sleep-phase syndrome (FASPS) [MIM:604348]. FASPS is characterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and melatonin rhythms. -
Sequence similarities
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Contains 1 protein kinase domain. -
Post-translational
modificationsAutophosphorylated on serine and threonine residues. -
Cellular localization
Cytoplasm. Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 1453 Human
- Entrez Gene: 104318 Mouse
- Omim: 600864 Human
- SwissProt: P48730 Human
- SwissProt: Q9DC28 Mouse
- Unigene: 631725 Human
- Unigene: 216227 Mouse
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Alternative names
- Casein Kinase 1 delta antibody
- Casein kinase I delta isoform antibody
- Casein kinase I isoform delta antibody
see all
Datasheets and documents
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SDS download
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Datasheet download
References (4)
ab10877 has been referenced in 4 publications.
- Lin SH et al. Casein kinase 1 epsilon expression predicts poorer prognosis in low T-stage oral cancer patients. Int J Mol Sci 15:2876-91 (2014). IHC-P ; Human . PubMed: 24557581
- Löhler J et al. Immunohistochemical characterisation of cell-type specific expression of CK1delta in various tissues of young adult BALB/c mice. PLoS One 4:e4174 (2009). IHC-P ; Mouse . PubMed: 19137063
- Brockschmidt C et al. Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo. Gut 57:799-806 (2008). PubMed: 18203806
- Fernández-Medarde A et al. Laser microdissection and microarray analysis of the hippocampus of Ras-GRF1 knockout mice reveals gene expression changes affecting signal transduction pathways related to memory and learning. Neuroscience 146:272-85 (2007). PubMed: 17321057