Anti-Casein Kinase 1 delta/CSNK1D antibody (ab10877)

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Overview

  • Product name

    Anti-Casein Kinase 1 delta/CSNK1D antibody
    See all Casein Kinase 1 delta/CSNK1D primary antibodies

  • Description

    Goat polyclonal to Casein Kinase 1 delta/CSNK1D

  • Host species

    Goat

  • Specificity

    ab10877 is specific for human Casein Kinase 1 delta/CSNK1D.

  • Tested applications

    Suitable for: ELISA, IHC-Pmore details

  • Species reactivity

    Reacts with: Mouse, Human

  • Immunogen

    Synthetic peptide corresponding to Human Casein Kinase 1 delta/CSNK1D aa 310-327 (C terminal).

  • General notes

    Previously labelled as Casein Kinase 1 delta. 

Properties

Applications

Our Abpromise guarantee covers the use of ab10877 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.
IHC-P 1/200. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm.

  • Tissue specificity

    Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes.

  • Involvement in disease

    Defects in CSNK1D are a cause of familial advanced sleep-phase syndrome (FASPS) [MIM:604348]. FASPS is characterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and melatonin rhythms.

  • Sequence similarities

    Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
    Contains 1 protein kinase domain.

  • Post-translational
    modifications

    Autophosphorylated on serine and threonine residues.

  • Cellular localization

    Cytoplasm. Nucleus.
  • Information by UniProt

  • Database links

    • Alternative names

      • Casein Kinase 1 delta antibody
      • Casein kinase I delta isoform antibody
      • Casein kinase I isoform delta antibody
      • CKI delta antibody
      • CKI-delta antibody
      • CKId antibody
      • CKIdelta antibody
      • CSNK 1D antibody
      • CSNK1D antibody
      • HCKID antibody
      • KC1D_HUMAN antibody
      • Protein kinase CK1 delta antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Casein Kinase 1 delta/CSNK1D antibody (ab10877)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Casein Kinase 1 delta/CSNK1D antibody (ab10877)Image from Lohler J et. al., PLoS ONE. 2009; 4(1): e4174 (Fig 2C).

      ab10877 at 1/200 dilution staining Casein Kinase 1 delta/CSNK1D in mouse skeletal muscle tissue section by Immunohistochemistry. Tissue samples from 4 to 6 week old BALB/c mice were immediately removed after killing and immersion fixed in Bouin's solution. Primary antibody was used for 40 minutes at RT. Specific antibody binding was visualised by the peroxidase reaction using DAB as substrate-chromogen.

    References

    This product has been referenced in:

    • Lin SH  et al. Casein kinase 1 epsilon expression predicts poorer prognosis in low T-stage oral cancer patients. Int J Mol Sci 15:2876-91 (2014). IHC-P ; Human . Read more (PubMed: 24557581) »
    • Löhler J  et al. Immunohistochemical characterisation of cell-type specific expression of CK1delta in various tissues of young adult BALB/c mice. PLoS One 4:e4174 (2009). IHC-P ; Mouse . Read more (PubMed: 19137063) »
    See all 4 Publications for this product

    Publishing research using ab10877? Please let us know so that we can cite the reference in this datasheet.

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