Overview

  • Product name

    Anti-Casein Kinase 1 delta/CSNK1D antibody
    See all Casein Kinase 1 delta/CSNK1D primary antibodies
  • Description

    Rabbit polyclonal to Casein Kinase 1 delta/CSNK1D
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat, Cow
  • Immunogen

    Recombinant fragment corresponding to Human Casein Kinase 1 delta/CSNK1D aa 144-361.

  • Positive control

    • HeLa and BCL-1 whole cell lysates; HeLa cells; Human hepatoma tissue.
  • General notes

    Previously labelled as Casein Kinase 1 delta. 

Properties

Applications

Our Abpromise guarantee covers the use of ab151793 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 47 kDa.
IHC-P 1/100 - 1/1000.
ICC/IF 1/100 - 1/1000.

Target

  • Function

    Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm.
  • Tissue specificity

    Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes.
  • Involvement in disease

    Defects in CSNK1D are a cause of familial advanced sleep-phase syndrome (FASPS) [MIM:604348]. FASPS is characterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and melatonin rhythms.
  • Sequence similarities

    Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications

    Autophosphorylated on serine and threonine residues.
  • Cellular localization

    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • Casein Kinase 1 delta antibody
    • Casein kinase I delta isoform antibody
    • Casein kinase I isoform delta antibody
    • CKI delta antibody
    • CKI-delta antibody
    • CKId antibody
    • CKIdelta antibody
    • CSNK 1D antibody
    • CSNK1D antibody
    • HCKID antibody
    • KC1D_HUMAN antibody
    • Protein kinase CK1 delta antibody
    see all

Images

  • Anti-Casein Kinase 1 delta/CSNK1D antibody (ab151793) at 1/2000 dilution + BCL-1 whole cell lysate at 30 µg

    Predicted band size: 47 kDa



    10% SDS PAGE
  • Anti-Casein Kinase 1 delta/CSNK1D antibody (ab151793) at 1/2000 dilution + HeLa cell lysate at 30 µg

    Predicted band size: 47 kDa



    10% SDS PAGE
  • Confocal immunofluorescence analysis of paraformaldehyde-fixed HeLa cells, labeling Casein Kinase 1 delta/CSNK1D with ab151793 at 1/500 dilution (green). Alpha-tubulin filaments were also labeled (Red).

  • Immunohistochemical analysis of paraffin-embedded Human hepatoma tissue, labeling Casein Kinase 1 delta/CSNK1D with ab151793 at 1/500 dilution.

References

ab151793 has not yet been referenced specifically in any publications.

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