Product nameAnti-Caspase 4 antibody
See all Caspase 4 primary antibodies
DescriptionRabbit polyclonal to Caspase 4
Specificityab22687 recognises proenzyme (43 kDa) and the large subunit (19 kDa) and small (10 kDa) subunits of mature enzyme. For the mature enzyme, reactivity is strongest with the large subunit. No cross reactivity with other human caspases tested (1 to 3, 5 to 10, 14).
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Recombinant full length protein (Human): Caspase 4
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferPreservative: 0.05% Sodium azide
Constituent: Whole serum
Our Abpromise guarantee covers the use of ab22687 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionInvolved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1.
Tissue specificityWidely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.
Sequence similaritiesBelongs to the peptidase C14A family.
Contains 1 CARD domain.
modificationsThe two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8.
- Information by UniProt
- Apoptotic cysteine protease Mih1/TX antibody
- CASP-4 antibody
- CASP4 antibody
This product has been referenced in:
- Kaul Z & Chakrabarti O Tumor susceptibility gene 101 regulates predisposition to apoptosis via ESCRT machinery accessory proteins. Mol Biol Cell 28:2106-2122 (2017). Read more (PubMed: 28539405) »
- Moorwood C & Barton ER Caspase-12 ablation preserves muscle function in the mdx mouse. Hum Mol Genet 23:5325-41 (2014). Read more (PubMed: 24879640) »