Castanospermine, alpha- and beta-glucosidase activity inhibitor (ab142851)

Overview

  • Product name

    Castanospermine, alpha- and beta-glucosidase activity inhibitor
  • Description

    Potent sucrase (Ki =2.6 nM) and α- and β-glucosidase activity inhibitor.
  • Biological description

    Potent sucrase (Ki =2.6 nM) and alpha and beta glucosidase activity inhibitor. Shows antiviral activity. Anti-inflammatory and immunosuppressive agent. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    79831-76-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1S,6S,7R,8R,8aR)-1,2,3,5,6,7,8,8a-Octahydroindolizine-1,6,7,8-tetrol
  • Molecular weight

    189.21
  • Molecular formula

    C8H15NO4
  • PubChem identifier

    54445
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 75 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CN2CC(C(C(C2C1O)O)O)O
  • Source

    Castanospermum australe

  • Research areas

References

This product has been referenced in:

  • Whitby K  et al. Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo. J Virol 79:8698-706 (2005). Read more (PubMed: 15994763) »
  • Trugnan G  et al. Castanospermine: a potent inhibitor of sucrase from the human enterocyte-like cell line Caco-2. FEBS Lett 195:28-32 (1986). Read more (PubMed: 2867936) »
  • Saul R  et al. Studies on the mechanism of castanospermine inhibition of alpha- and beta-glucosidases. Arch Biochem Biophys 230:668-75 (1984). Read more (PubMed: 6424575) »

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