Catharanthine sulfate, Vinblastine-type alkaloid precursor (ab142654)

Overview

  • Product name

    Catharanthine sulfate, Vinblastine-type alkaloid precursor
  • Description

    Vinblastine-type alkaloid precursor
  • Biological description

    Vinblastine-type alkaloid precursor. Antitumor activity. Inhibits AChR by ion channel blocking and desensitization. Regulates amylase release by causing a rise in cytoplasmic Ca2+.
  • Purity

    > 98%
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Catharanthine sulfate
  • Molecular weight

    434.51
  • Molecular formula

    C21H26N2O6S
  • PubChem identifier

    429464
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCC1=CC2CC3(C1N(C2)CCC4=C3NC5=CC=CC=C45)C(=O)OC.OS(=O)(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Jadhav A  et al. Catharanthine dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes. J Pharmacol Exp Ther 345:383-92 (2013). Read more (PubMed: 23532933) »
  • Arias HR  et al. Catharanthine alkaloids are noncompetitive antagonists of muscle-type nicotinic acetylcholine receptors. Neurochem Int 57:153-61 (2010). Read more (PubMed: 20493225) »
  • Williams JA Catharanthine: a novel stimulator of pancreatic enzyme release. Cell Tissue Res 192:277-84 (1978). Read more (PubMed: 699016) »

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