Key features and details
- Rabbit polyclonal to Cathepsin C
- Suitable for: Dot blot, WB, ICC/IF
- Reacts with: Cow
- Isotype: IgG
Product nameAnti-Cathepsin C antibody
See all Cathepsin C primary antibodies
DescriptionRabbit polyclonal to Cathepsin C
Tested applicationsSuitable for: Dot blot, WB, ICC/IFmore details
Species reactivityReacts with: Cow
Full length native protein (purified) corresponding to Cow Cathepsin C. (Isolated and purified from bovine spleen).
Database link: Q3ZCJ8
This product was previously labelled as DPP1
FormLyophilized:Reconstitute by adding 1mL of sterile distilled water. Spin down to remove insoluble particles.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.20
Constituents: PBS, Dextran
No preservative added. No foreign protein added.
Concentration information loading...
Our Abpromise guarantee covers the use of ab182904 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Dot blot||1/1000 - 1/5000.|
|WB||1/1000 - 1/5000. Predicted molecular weight: 52 kDa.|
|ICC/IF||1/1000 - 1/5000.|
FunctionThiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII.
Tissue specificityUbiquitous. Highly expressed in lung, kidney and placenta. Detected at intermediate levels in colon, small intestine, spleen and pancreas.
Involvement in diseasePapillon-Lefevre syndrome
Periodontititis, aggressive, 1
Sequence similaritiesBelongs to the peptidase C1 family.
modificationsN-glycosylated. While glycosylation at Asn-53, Asn-119 and Asn-276 is mediated by STT3A-containing complexes, glycosylation at Asn-29 is mediated STT3B-containing complexes.
In approximately 50% of the complexes the exclusion domain is cleaved at position 58 or 61. The two parts of the exclusion domain are held together by a disulfide bond.
- Information by UniProt
- AI047818 antibody
- CATC antibody
- CATC_HUMAN antibody
ab182904 has been referenced in 1 publication.
- Nakamura K et al. Effects of miR-98 in intrauterine extracellular vesicles on maternal immune regulation during the peri-implantation period in cattle. Sci Rep 9:20330 (2019). PubMed: 31889113