Key features and details
- Rabbit polyclonal to Cathepsin C - C-terminal
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Cathepsin C antibody - C-terminal
See all Cathepsin C primary antibodies
DescriptionRabbit polyclonal to Cathepsin C - C-terminal
Tested applicationsSuitable for: IHC-P, WBmore details
Species reactivityReacts with: Human
Synthetic peptide within Human Cathepsin C (C terminal). The exact sequence is proprietary. from Isoform 3. NCBI Accession No. NP_001107645.
Database link: P53634-3
- Human placenta tissue lysate or Human thyroid cancer tissue.
This product was previously labelled as DPP1
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.30
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol, 49% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab199109 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|
|WB||1/500 - 1/2000. Predicted molecular weight: 16 kDa.|
FunctionThiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII.
Tissue specificityUbiquitous. Highly expressed in lung, kidney and placenta. Detected at intermediate levels in colon, small intestine, spleen and pancreas.
Involvement in diseasePapillon-Lefevre syndrome
Periodontititis, aggressive, 1
Sequence similaritiesBelongs to the peptidase C1 family.
modificationsN-glycosylated. While glycosylation at Asn-53, Asn-119 and Asn-276 is mediated by STT3A-containing complexes, glycosylation at Asn-29 is mediated STT3B-containing complexes.
In approximately 50% of the complexes the exclusion domain is cleaved at position 58 or 61. The two parts of the exclusion domain are held together by a disulfide bond.
- Information by UniProt
- AI047818 antibody
- CATC antibody
- CATC_HUMAN antibody
ab199109 has not yet been referenced specifically in any publications.