Overview

  • Product name

    Anti-Cathepsin C antibody - C-terminal
    See all Cathepsin C primary antibodies
  • Description

    Rabbit polyclonal to Cathepsin C - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human Cathepsin C (C terminal). The exact sequence is proprietary. from Isoform 3. NCBI Accession No. NP_001107645.
    Database link: P53634-3

  • Positive control

    • Human placenta tissue lysate or Human thyroid cancer tissue.
  • General notes

     This product was previously labelled as DPP1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab199109 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/500 - 1/2000. Predicted molecular weight: 16 kDa.

Target

  • Function

    Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII.
  • Tissue specificity

    Ubiquitous. Highly expressed in lung, kidney and placenta. Detected at intermediate levels in colon, small intestine, spleen and pancreas.
  • Involvement in disease

    Papillon-Lefevre syndrome
    Haim-Munk syndrome
    Periodontititis, aggressive, 1
  • Sequence similarities

    Belongs to the peptidase C1 family.
  • Post-translational
    modifications

    N-glycosylated. While glycosylation at Asn-53, Asn-119 and Asn-276 is mediated by STT3A-containing complexes, glycosylation at Asn-29 is mediated STT3B-containing complexes.
    In approximately 50% of the complexes the exclusion domain is cleaved at position 58 or 61. The two parts of the exclusion domain are held together by a disulfide bond.
  • Cellular localization

    Lysosome.
  • Information by UniProt
  • Database links

  • Alternative names

    • AI047818 antibody
    • CATC antibody
    • CATC_HUMAN antibody
    • Cathepsin C antibody
    • Cathepsin J antibody
    • CPPI antibody
    • CTSC antibody
    • Dipeptidyl peptidase 1 antibody
    • Dipeptidyl peptidase 1 light chain antibody
    • Dipeptidyl peptidase I antibody
    • Dipeptidyl peptidase I exclusion domain chain antibody
    • Dipeptidyl peptidase I heavy chain antibody
    • Dipeptidyl peptidase I light chain antibody
    • Dipeptidyl transferase antibody
    • DPP I antibody
    • DPP-I antibody
    • DPPI antibody
    • EC 3.4.14.1 antibody
    • HMS antibody
    • JP antibody
    • JPD antibody
    • MGC126959 antibody
    • PALS antibody
    • PDON1 antibody
    • PLS antibody
    see all

Images

  • Anti-Cathepsin C antibody - C-terminal (ab199109) at 1/1000 dilution + Human placenta tissue lysate at 40 µg

    Predicted band size: 16 kDa

  • Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling Cathepsin C using ab199109 at a 1/50 dilution.

References

ab199109 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab199109.
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