Recombinant Anti-Cathepsin C antibody [EPR7749] - C-terminal (ab192019)


  • Product name

    Anti-Cathepsin C antibody [EPR7749] - C-terminal
    See all Cathepsin C primary antibodies
  • Description

    Rabbit monoclonal [EPR7749] to Cathepsin C - C-terminal
  • Host species

  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide within Human Cathepsin C aa 450 to the C-terminus (C terminal). The exact sequence is proprietary.
    Database link: P53634

  • Positive control

    • HT29, JAR and A549 cell lysates; Human Cathepsin C recombinant protein; A549 cells.
  • General notes



     This product was previously labelled as DPP1


    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.



Our Abpromise guarantee covers the use of ab192019 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Detects a band of approximately 55 kDa (predicted molecular weight: 52 kDa).


  • Function

    Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII.
  • Tissue specificity

    Ubiquitous. Highly expressed in lung, kidney and placenta. Detected at intermediate levels in colon, small intestine, spleen and pancreas.
  • Involvement in disease

    Papillon-Lefevre syndrome
    Haim-Munk syndrome
    Periodontititis, aggressive, 1
  • Sequence similarities

    Belongs to the peptidase C1 family.
  • Post-translational

    N-glycosylated. While glycosylation at Asn-53, Asn-119 and Asn-276 is mediated by STT3A-containing complexes, glycosylation at Asn-29 is mediated STT3B-containing complexes.
    In approximately 50% of the complexes the exclusion domain is cleaved at position 58 or 61. The two parts of the exclusion domain are held together by a disulfide bond.
  • Cellular localization

  • Information by UniProt
  • Database links

  • Alternative names

    • AI047818 antibody
    • CATC antibody
    • CATC_HUMAN antibody
    • Cathepsin C antibody
    • Cathepsin J antibody
    • CPPI antibody
    • CTSC antibody
    • Dipeptidyl peptidase 1 antibody
    • Dipeptidyl peptidase 1 light chain antibody
    • Dipeptidyl peptidase I antibody
    • Dipeptidyl peptidase I exclusion domain chain antibody
    • Dipeptidyl peptidase I heavy chain antibody
    • Dipeptidyl peptidase I light chain antibody
    • Dipeptidyl transferase antibody
    • DPP I antibody
    • DPP-I antibody
    • DPPI antibody
    • EC antibody
    • HMS antibody
    • JP antibody
    • JPD antibody
    • MGC126959 antibody
    • PALS antibody
    • PDON1 antibody
    • PLS antibody
    see all


  • All lanes : Anti-Cathepsin C antibody [EPR7749] - C-terminal (ab192019) at 1/1000 dilution

    Lane 1 : HT29 cell lysates
    Lane 2 : JAR cell lysates
    Lane 3 : A549 cell lysates

    Lysates/proteins at 20 µg per lane.

    All lanes : Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

    Developed using the ECL technique.

    Predicted band size: 52 kDa
    Observed band size: 55 kDa
    why is the actual band size different from the predicted?

  • Anti-Cathepsin C antibody [EPR7749] - C-terminal (ab192019) at 1/1000 dilution + Human Cathepsin C recombinant protein at 0.01 µg

    Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

    Developed using the ECL technique.

    Predicted band size: 52 kDa
    Observed band size: 55 kDa why is the actual band size different from the predicted?

  • Flow cytometric analysis of 2% paraformaldehyde fixed A549 cells labeling Cathepsin C with ab192019 at a 1/340 dilution (red) compared to a Rabbit monoclonal IgG isotype control (green).  Secondary staining was with Goat anti Rabbit IgG (FITC) at 1/50 dilution.


ab192019 has not yet been referenced specifically in any publications.

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