Key features and details
- Rabbit polyclonal to Cathepsin D
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Cathepsin D antibody
See all Cathepsin D primary antibodies
DescriptionRabbit polyclonal to Cathepsin D
Specificityab49787 recognizes the light chain of cleaved cathepsin D, as well as the intact zymogen.
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
A synthetic peptide based on the N terminus of the light chain of human cathepsin D
Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Storage bufferpH: 7.40
Preservative: 0.05% Sodium azide
Constituents: PBS, 50% Glycerol, 2.9% Sodium chloride
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab49787 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
FunctionAcid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
Tissue specificityExpressed in the aorta extrcellular space (at protein level).
Involvement in diseaseCeroid lipofuscinosis, neuronal, 10
Sequence similaritiesBelongs to the peptidase A1 family.
Contains 1 peptidase A1 domain.
modificationsN- and O-glycosylated.
Cellular localizationLysosome. Melanosome. Secreted, extracellular space. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380).
- Information by UniProt
- CatD antibody
- CATD_HUMAN antibody
- Cathepsin D antibody
All lanes : Anti-Cathepsin D antibody (ab49787) at 1/1000 dilution
Lane 1 : Recombinant Human Cathepsin D at 0.04 µg
Lane 2 : Recombinant Human Cathepsin D at 0.02 µg
Lane 3 : Recombinant Human Cathepsin D at 0.01 µg
Lane 4 : Recombinant Human Cathepsin D at 0.004 µg
Lane 5 : Recombinant Human Cathepsin D at 0.002 µg
Predicted band size: 46 kDa
Observed band size: 48 kDa why is the actual band size different from the predicted?
ab49787 has been referenced in 1 publication.
- Harrell JC et al. Estrogen insensitivity in a model of estrogen receptor positive breast cancer lymph node metastasis. Cancer Res 67:10582-91 (2007). PubMed: 17975003