Key features and details
- Rabbit polyclonal to Cathepsin E
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-Cathepsin E antibody
See all Cathepsin E primary antibodies
DescriptionRabbit polyclonal to Cathepsin E
SpecificityThis antibody is specific for Cathepsin E.
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse, Rat, Human
A synthetic peptide made to the C-terminus of mouse Cathepsin E.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.05% Sodium azide
Constituent: Whole serum
Concentration information loading...
Our Abpromise guarantee covers the use of ab36996 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/1000. Predicted molecular weight: 42 kDa.|
FunctionMay have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.
Tissue specificityExpressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B-lymphocytes.
Sequence similaritiesBelongs to the peptidase A1 family.
modificationsGlycosylated. The nature of the carbohydrate chain varies between cell types. In fibroblasts, the proenzyme contains a high mannose-type oligosaccharide, while the mature enzyme contains a complex-type oligosaccharide. In erythrocyte membranes, both the proenzyme and mature enzyme contain a complex-type oligosaccharide.
Two forms are produced by autocatalytic cleavage, form I begins at Ile-54, form II begins at Thr-57.
Cellular localizationEndosome. The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.
- Information by UniProt
- CATE antibody
- CATE_HUMAN antibody
- Cathepsin E antibody
ab36996 has been referenced in 4 publications.
- Ye X et al. Lipopolysaccharide induces neuroinflammation in microglia by activating the MTOR pathway and downregulating Vps34 to inhibit autophagosome formation. J Neuroinflammation 17:18 (2020). PubMed: 31926553
- Fisher OM et al. High Expression of Cathepsin E in Tissues but Not Blood of Patients with Barrett's Esophagus and Adenocarcinoma. Ann Surg Oncol 22:2431-8 (2015). IHC . PubMed: 25348778
- Fristrup N et al. Cathepsin E, maspin, Plk1, and survivin are promising prognostic protein markers for progression in non-muscle invasive bladder cancer. Am J Pathol 180:1824-34 (2012). IHC-P ; Human . PubMed: 22449953
- Li XL et al. An essential role for the antiviral endoribonuclease, RNase-L, in antibacterial immunity. Proc Natl Acad Sci U S A 105:20816-21 (2008). ICC/IF ; Mouse . PubMed: 19075243