Overview

  • Product name

    Cathepsin G Inhibitor, cathepsin G inhibitor
  • Description

    Cell-permeable, potent, selective, reversible, competitive cathepsin G inhibitor
  • Biological description

    Cell-permeable, potent, selective, reversible, competitive cathepsin G inhibitor (IC50 = 0.53 μM). Ameliorates extracellular matrix damage and upregulates MMPs. Active in vitro and in vivo.
  • Purity

    > 98%
  • CAS Number

    429676-93-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [2-[3-[(1-Benzoylpiperidin-4-yl)methylcarbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2-oxoethyl]phosphonic acid
  • Molecular weight

    620.63
  • Molecular formula

    C36H33N2O6P
  • PubChem identifier

    9830518
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 5 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN(C1CCN(CC1)C(=O)C2=CC=CC=C2)C(=O)C3=CC4=CC=CC=C4C=C3C(=O)C(C5=CC=CC6= CC=CC=C65)P(=O)(O)O
  • Source

    Synthetic

  • Research areas

Associated products

References

This product has been referenced in:

  • Son ED  et al. Cathepsin G inhibitor prevents ultraviolet B-induced photoaging in hairless mice via inhibition of fibronectin fragmentation. Dermatology 224:352-60 (2012). Read more (PubMed: 22759782) »
  • Reich M  et al. Application of specific cell permeable cathepsin G inhibitors resulted in reduced antigen processing in primary dendritic cells. Mol Immunol 46:2994-9 (2009). Read more (PubMed: 19615749) »
  • Maryanoff BE Inhibitors of serine proteases as potential therapeutic agents: the road from thrombin to tryptase to cathepsin G. J Med Chem 47:769-87 (2004). Read more (PubMed: 14761180) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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